Technology Process of tert-butyl 3-(4-methoxyphenyl)-2-methylpropanoate
There total 2 articles about tert-butyl 3-(4-methoxyphenyl)-2-methylpropanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 2-methylpropanoate;
With
lithium dicyclohexylamide;
In
toluene;
at 20 ℃;
for 0.25h;
Inert atmosphere;
1-bromo-4-methoxy-benzene;
With
tris-(dibenzylideneacetone)dipalladium(0); DavePhos;
In
toluene;
at 30 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/chem.201103153
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuric acid; magnesium sulfate / dichloromethane / 20 °C
2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1.5 h / -78 - 20 °C
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sulfuric acid; magnesium sulfate; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 1.5 h / -78 - 20 °C
2.1: iodine; silver sulfate / ethanol / 1 h / 20 °C
3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; iodine; potassium acetate; silver sulfate; lithium diisopropyl amide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide;
