methyl 2-amino-5-isobutoxybenzoate

Base Information

• Chemical Name: methyl 2-amino-5-isobutoxybenzoate
• CAS No.: 1103931-28-7
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.272
• Mol file: 1103931-28-7.mol

Synonyms:methyl 2-amino-5-isobutoxybenzoate

Chemical Property of methyl 2-amino-5-isobutoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-amino-5-isobutoxybenzoate

There total 3 articles about methyl 2-amino-5-isobutoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-acetamido-5-isobutoxybenzoate (1103931-26-5) → methyl 2-amino-5-isobutoxybenzoate (1103931-28-7)

Guidance literature:

methyl 2-acetamido-5-isobutoxybenzoate; With hydrogenchloride; methanol; for 2h; Heating / reflux;

With water; sodium hydrogencarbonate; In ethyl acetate;

Reference yield: 84.0%

C12H15NO5 → methyl 2-amino-5-isobutoxybenzoate (1103931-28-7)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; at 55 ℃;

DOI:10.1002/ejoc.201700181

Reference yield:

5-chloro-2-nitrobenzoic acid (2516-95-2) → methyl 2-amino-5-isobutoxybenzoate (1103931-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 24 h / Reflux

1.2: 12 h / Reflux

1.3: 95 °C

2.1: tin(II) chloride dihdyrate / ethyl acetate / 55 °C

With tin(II) chloride dihdyrate; sodium hydroxide; In water; ethyl acetate;

DOI:10.1002/ejoc.201700181

upstream raw materials:

methyl 2-acetamido-5-isobutoxybenzoate

5-chloro-2-nitrobenzoic acid

Downstream raw materials:

C₂₂H₂₄N₂O₆