3,4-Dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one

Base Information

• Chemical Name: 3,4-Dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one
• CAS No.: 50624-06-1
• Molecular Formula: C₁₃H₁₂O₄
• Molecular Weight: 232.236
• Hs Code.: 2932999099
• Mol file: 50624-06-1.mol

Synonyms:3,4-Dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one;3,4-dihydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one;BB_SC-4360;Oprea1_647310

Chemical Property of 3,4-Dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one

Chemical Property:

• PSA: 70.67000
• LogP: 2.08300

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one

There total 6 articles about 3,4-Dihydroxy-7,8,9,10-tetrahydro-6H-benzo[c]-chromen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-oxocyclohexane carboxylate (1655-07-8) + 2-hydroxyresorcinol (87-66-1) → 3,4-dihydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one (50624-06-1)

Guidance literature:

With aluminum oxide; methanesulfonic acid; at 20 ℃; for 0.0833333h;

DOI:10.1016/S0385-5414(07)81208-1

Reference yield:

C15H13F13O3 (911217-74-8) + 2-hydroxyresorcinol (87-66-1) → 3,4-dihydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one (50624-06-1)

Guidance literature:

With sulfuric acid; In ethyl acetate; at 20 ℃; for 12h;

DOI:10.1039/b607710b

Reference yield:

7-O-(2’’,3’’,4’’,6’’-tetra-O-acetyl-β-D-galactopyranosyl)-8-hydroxy-3,4-cyclohexenocoumarin (1413789-91-9) → 3,4-dihydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one (50624-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia; methanol / 0 - 20 °C

2: aq. phosphate buffer / 20 - 22 °C / pH 7.4

With methanol; ammonia; In aq. phosphate buffer;

DOI:10.1002/cplu.201100072

upstream raw materials:

ethyl 2-oxocyclohexane carboxylate

2-hydroxyresorcinol

C₁₅H₁₃F₁₃O₃

7-O-(2’’,3’’,4’’,6’’-tetra-O-acetyl-β-D-galactopyranosyl)-8-hydroxy-3,4-cyclohexenocoumarin