2-Pyridinepropanoic acid, a-aMino-, Methyl ester

Base Information

• Chemical Name: 2-Pyridinepropanoic acid, a-aMino-, Methyl ester
• CAS No.: 172927-00-3
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Mol file: 172927-00-3.mol

Synonyms:2-Pyridinepropanoic acid, a-aMino-, Methyl ester;2-Pyridinepropanoic acid, α-amino-, methyl ester, (S)- (9CI)

Chemical Property of 2-Pyridinepropanoic acid, a-aMino-, Methyl ester

Chemical Property:

• PSA: 65.21000
• LogP: 0.82470

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-amino-3-(pyridin-2-yl)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinepropanoic acid, a-aMino-, Methyl ester

There total 2 articles about 2-Pyridinepropanoic acid, a-aMino-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(L)-2-pyridylalanine methyl ester dihydrochloride (163513-22-2) → 3-(pyridin-2-yl)-DL-alanine methyl ester (172927-00-3)

Guidance literature:

With Amberlyst A-21;

Reference yield:

→ 3-(pyridin-2-yl)-DL-alanine methyl ester (172927-00-3)

Guidance literature:

Reference yield: 5.0%

N-(3-Chlorobenzyl)-4-formyl-3-nitrobenzamide (1002110-72-6) + 3-(pyridin-2-yl)-DL-alanine methyl ester (172927-00-3) → methyl (2R)-2-(6-{[(3-chlorobenzyl)amino]carbonyl}-2H-indazol-2-yl)-3-pyridin-2-yl-propanoate (1002110-04-4)

Guidance literature:

N-(3-Chlorobenzyl)-4-formyl-3-nitrobenzamide; 3-(pyridin-2-yl)-DL-alanine methyl ester; With trimethyl orthoformate; In acetonitrile; at 20 ℃; for 16h;

With triethyl phosphite; at 105 ℃; for 3h; Inert atmosphere;

upstream raw materials:

(L)-2-pyridylalanine methyl ester dihydrochloride

Downstream raw materials:

methyl (2R)-2-(6-{[(3-chlorobenzyl)amino]carbonyl}-2H-indazol-2-yl)-3-pyridin-2-yl-propanoate

Refernces

• 1、 -. "HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE". Page 73. . Retrieved 2010/02/07.