Quinazoline, 4-(3-chlorophenoxy)-2-(4-methyl-1-piperazinyl)-

Base Information

Chemical Name:Quinazoline, 4-(3-chlorophenoxy)-2-(4-methyl-1-piperazinyl)-
CAS No.:129112-36-3
Molecular Formula:C19H19 Cl N4 O
Molecular Weight:354.8334
Hs Code.:
DSSTox Substance ID:DTXSID90156065
Nikkaji Number:J272.392A
Wikidata:Q83024071

Synonyms:BRN 3629215;Quinazoline, 4-(3-chlorophenoxy)-2-(4-methyl-1-piperazinyl)-;4-(3-Chlorophenoxy)-2-(4-methyl-1-piperazinyl)quinazoline;129112-36-3;C19H19ClN4O;DTXSID90156065;LS-140074;2-[4-Methyl-1-piperazinyl]-4-(3-chlorophenoxy)quinazoline

Suppliers and Price of Quinazoline, 4-(3-chlorophenoxy)-2-(4-methyl-1-piperazinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Quinazoline, 4-(3-chlorophenoxy)-2-(4-methyl-1-piperazinyl)-

Chemical Property:

Vapor Pressure:4.07E-11mmHg at 25°C
Boiling Point:525°Cat760mmHg
Flash Point:271.3°C
Density:1.286g/cm³
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:354.1247389
Heavy Atom Count:25
Complexity:432

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)OC4=CC(=CC=C4)Cl

Technology Process of Quinazoline, 4-(3-chlorophenoxy)-2-(4-methyl-1-piperazinyl)-

There total 4 articles about Quinazoline, 4-(3-chlorophenoxy)-2-(4-methyl-1-piperazinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 108-43-0
3-monochlorophenol

: 39213-06-4
4-Chloro-2-(4-methyl-1-piperazinyl)quinazoline

: 129112-36-3
4-(3-Chloro-phenoxy)-2-(4-methyl-piperazin-1-yl)-quinazoline

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1248/cpb.38.681

Reference yield:

: 109-01-3
1-methyl-piperazine

: 129112-36-3
4-(3-Chloro-phenoxy)-2-(4-methyl-piperazin-1-yl)-quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 155 - 160 °C

2: 88 percent / POCl₃ / 130 °C

3: 71 percent / 60percent NaH / dimethylformamide / 60 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.681

Reference yield:

: 16822-65-4
2-(4-methylpiperazin-1-yl)quinazolin-4(3H)-one

: 129112-36-3
4-(3-Chloro-phenoxy)-2-(4-methyl-piperazin-1-yl)-quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / POCl₃ / 130 °C

2: 71 percent / 60percent NaH / dimethylformamide / 60 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.681