3-(4-Methoxyphenyl)oxetane-3-carboxylic acid

Base Information

• Chemical Name: 3-(4-Methoxyphenyl)oxetane-3-carboxylic acid
• CAS No.: 1416323-25-5
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.214
• Hs Code.: 2932990090
• Mol file: 1416323-25-5.mol

Synonyms:3-(4-Methoxyphenyl)oxetane-3-carboxylic acid

Chemical Property of 3-(4-Methoxyphenyl)oxetane-3-carboxylic acid

Chemical Property:

• PSA: 55.76000
• LogP: 1.04780

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Methoxyphenyl)oxetane-3-carboxylicacid 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Methoxyphenyl)oxetane-3-carboxylic acid

There total 8 articles about 3-(4-Methoxyphenyl)oxetane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(3-(4-methoxyphenyl)oxetan-3-yl)-5-methylfuran → 3-(4-methoxyphenyl)oxetane-3-carboxylic acid (1416323-25-5)

Guidance literature:

2-(3-(4-methoxyphenyl)oxetan-3-yl)-5-methylfuran; With sodium periodate; water; In n-heptane; ethyl acetate; for 0.0833333h;

With ruthenium trichloride; In n-heptane; ethyl acetate; at 0 - 25 ℃; for 18h; Reagent/catalyst;

DOI:10.1021/acs.orglett.0c01214

Reference yield: 66.8%

C12H14O2 → 3-(4-methoxyphenyl)oxetane-3-carboxylic acid (1416323-25-5)

Guidance literature:

C₁₂H₁₄O₂; With ozone; In dichloromethane; at -78 - 20 ℃; for 12h;

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; acetonitrile; at 0 - 20 ℃; for 1.5h;

Reference yield:

3-(4-methoxyphenyl)oxetan-3-ol (26755-28-2) → 3-(4-methoxyphenyl)oxetane-3-carboxylic acid (1416323-25-5) + (Z)-1-(3-(4-methoxyphenyl)oxetan-3-yl)pent-2-ene-1,4-dione

Guidance literature:

Multi-step reaction with 2 steps

1: bis(trifluoromethane)sulfonimide lithium; tert-butylammonium hexafluorophosphate(V) / toluene / 2 h / 40 °C / Inert atmosphere

2: sodium periodate; ruthenium trichloride; water / acetonitrile / 18 h / 25 °C

With ruthenium trichloride; sodium periodate; water; tert-butylammonium hexafluorophosphate(V); bis(trifluoromethane)sulfonimide lithium; In toluene; acetonitrile;

DOI:10.1021/acs.orglett.0c01214

upstream raw materials:

3-(4-methoxyphenyl)oxetan-3-ol

Refernces

• 1、 -. "Preparation method and application of 3-(substituted phenyl) oxetane-3-carboxylic acid and intermediate thereof". . . Retrieved 2020/11/12.