2-(4-Iodobutoxy)tetrahydropyran

Base Information

• Chemical Name: 2-(4-Iodobutoxy)tetrahydropyran
• CAS No.: 41049-30-3
• Molecular Formula: C9H17IO2
• Molecular Weight: 284.137
• DSSTox Substance ID: DTXSID10455542
• Nikkaji Number: J847.244K
• Mol file: 41049-30-3.mol

Synonyms:41049-30-3;2-(4-iodobutoxy)tetrahydropyran;2-(4-iodobutoxy)oxane;4-Iodobutyl Tetrahydropyranyl Ether;2-(4-Iodobutoxy)tetrahydro-2H-pyran;starbld0047270;SCHEMBL6466428;DTXSID10455542;GTUOMTZFCNDDBA-UHFFFAOYSA-N;2-(4-iodo-butoxy)-tetrahydro-pyran;FT-0670367;A1-04792

Chemical Property of 2-(4-Iodobutoxy)tetrahydropyran

Chemical Property:

• PSA: 18.46000
• LogP: 2.74480
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 284.02733
• Heavy Atom Count: 12
• Complexity: 109

Purity/Quality:

4-IodobutylTetrahydropyranylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)OCCCCI
• Uses: 4-Iodobutyl Tetrahydropyranyl Ether is used in the preparation of indoloylguanidine derivatives as Na+/H+ exchanger inhibitors.

Technology Process of 2-(4-Iodobutoxy)tetrahydropyran

There total 8 articles about 2-(4-Iodobutoxy)tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-iodo-butan-1-ol (3210-08-0) → 2-(4-iodobutoxy)tetrahydropyran (41049-30-3)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1016/S0040-4039(00)98216-9

Reference yield: 91.5%

4-(tetrahydropyran-2-yloxy)butan-1-ol (51326-51-3) → 2-(4-iodobutoxy)tetrahydropyran (41049-30-3)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; at -30 - 20 ℃; Inert atmosphere;

DOI:10.1002/cbdv.200800210

Reference yield: 90.0%

1-(methanesulfonoxy)-4-<(tetrahydropyran-2-yl)oxy>butane (77416-53-6) → 2-(4-iodobutoxy)tetrahydropyran (41049-30-3)

Guidance literature:

With sodium iodide; In acetone; Heating;

DOI:10.1016/S0040-4039(00)00709-7

upstream raw materials:

3,4-dihydro-2H-pyran

4-iodo-butan-1-ol

1-(methanesulfonoxy)-4-<(tetrahydropyran-2-yl)oxy>butane

1-chloro-4-tetrahydropyranyloxybutane

Downstream raw materials:

2-(hex-5-yn-1-yloxy)tetrahydro-2H-pyran

diphenyl[4-(tetrahydro-2H-pyran-2-yloxy)butyl]silane

1-chloro 4-iodobutane

2-phenyl 2[4(2-tetrahydropyranoxy)butyl] diethyl malonate