5-Benzyl-octahydropyrrolo[3,4-c]pyrrole-1,3-dione

Base Information

• Chemical Name: 5-Benzyl-octahydropyrrolo[3,4-c]pyrrole-1,3-dione
• CAS No.: 848591-86-6
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• Hs Code.: 2933990090
• European Community (EC) Number: 696-489-9
• DSSTox Substance ID: DTXSID70404319
• Mol file: 848591-86-6.mol

Synonyms:848591-86-6;5-benzyl-octahydropyrrolo[3,4-c]pyrrole-1,3-dione;5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione;5-Benzyl-tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione;5-Benzyl-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione;5-benzyl-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione;1211595-66-2;SCHEMBL583636;DTXSID70404319;COFHBZBIKPEYNP-UHFFFAOYSA-N;YIB59186;MFCD09025774;AKOS015839189;Pyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione, tetrahydro-5-(phenylmethyl)-;HG-0008;CS-0127611;FT-0694186;EN300-128994;5-benzyl-tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione;5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione;F1967-2428;5-(phenylmethyl)tetrahydropyrrolo[3,4-c]pyrrole-1,3(2h,3ah)-dione

Chemical Property of 5-Benzyl-octahydropyrrolo[3,4-c]pyrrole-1,3-dione

Chemical Property:

• Boiling Point: 416.3±38.0 °C(Predicted)
• PKA: 11.37±0.20(Predicted)
• PSA: 49.41000
• Density: 1.269±0.06 g/cm3(Predicted)
• LogP: 0.65770
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 230.105527694
• Heavy Atom Count: 17
• Complexity: 314

Purity/Quality:

97% ^*data from raw suppliers

5-Benzyl-octahydropyrrolo[3,4-c]pyrrole-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2C(CN1CC3=CC=CC=C3)C(=O)NC2=O

Technology Process of 5-Benzyl-octahydropyrrolo[3,4-c]pyrrole-1,3-dione

There total 5 articles about 5-Benzyl-octahydropyrrolo[3,4-c]pyrrole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.9%

maleiimide (541-59-3,25721-74-8) + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (848591-86-6)

Guidance literature:

maleiimide; N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 16.75h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 70.0%

2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione (165893-99-2) → 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (848591-86-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 25 ℃; for 12h;

Reference yield:

maleiimide (541-59-3,25721-74-8) + benzyl(methoxymethyl)trimethylsilanylmethylamine → 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (848591-86-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 19h;

upstream raw materials:

maleiimide

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione

2-acetyl-5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione

Downstream raw materials:

2-benzyloctahydropyrrolo[3,4-c]pyrrole

tert-butyl 5-benzylhexahydropyrrolo[3.4-c]pyrrole-2(1H)-carboxylate

tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

tert-butyl 5-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate