5-Nitro-3-phenylbenzoic acid

Base Information

• Chemical Name: 5-Nitro-3-phenylbenzoic acid
• CAS No.: 188355-96-6
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.219
• Hs Code.: 2916399090
• Mol file: 188355-96-6.mol

Synonyms:5-Nitro-3-phenylbenzoic acid;5-Nitro-[1,1'-biphenyl]-3-carboxylic acid

Chemical Property of 5-Nitro-3-phenylbenzoic acid

Chemical Property:

• Boiling Point: 454.8±45.0 °C(Predicted)
• PKA: 3.42±0.10(Predicted)
• PSA: 83.12000
• Density: 1.358±0.06 g/cm3(Predicted)
• LogP: 3.48320
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

5-Nitro-[1,1'-biphenyl]-3-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Nitro-3-phenylbenzoic acid

There total 1 articles about 5-Nitro-3-phenylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

bromobenzene (108-86-1,52753-63-6) + (3-(methoxycarbonyl)-5-nitrophenyl)boronic acid (117342-20-8) → 5-nitro-[1,1'-biphenyl]-3-carboxylic acid (188355-96-6)

Guidance literature:

bromobenzene; (3-(methoxycarbonyl)-5-nitrophenyl)boronic acid; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; In 1,4-dioxane; water; at 100 ℃; for 6h;

With hydrogenchloride; In water;

Reference yield: 81.0%

morpholine (110-91-8,99108-56-2) + 5-nitro-[1,1'-biphenyl]-3-carboxylic acid (188355-96-6) → morpholino-(5-nitro-[1,1'-biphenyl]-3-yl)methanone (1570262-20-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

upstream raw materials:

bromobenzene

(3-(methoxycarbonyl)-5-nitrophenyl)boronic acid

Downstream raw materials:

morpholino-(5-nitro-[1,1'-biphenyl]-3-yl)methanone

Refernces