2-broMo-3-Methyl-pyridine-3-carboxyl acid

Base Information

• Chemical Name: 2-broMo-3-Methyl-pyridine-3-carboxyl acid
• CAS No.: 1211516-25-4
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.034
• Hs Code.: 2933399090
• Mol file: 1211516-25-4.mol

Synonyms:2-broMo-3-Methyl-pyridine-3-carboxyl acid;6-BroMo-5-Methylpicolinic acid

Chemical Property of 2-broMo-3-Methyl-pyridine-3-carboxyl acid

Chemical Property:

• Boiling Point: 373.9±42.0 °C(Predicted)
• PKA: 3.42±0.10(Predicted)
• PSA: 50.19000
• Density: 1.692±0.06 g/cm3(Predicted)
• LogP: 1.85070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Bromo-5-methylpicolinicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-broMo-3-Methyl-pyridine-3-carboxyl acid

There total 4 articles about 2-broMo-3-Methyl-pyridine-3-carboxyl acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.8%

6-bromo-5-methylpyridine-2-carbonitrile (450844-27-6) → 6-bromo-5-methyl-pyridine-2-carboxylic acid (1211516-25-4)

Guidance literature:

6-bromo-5-methylpyridine-2-carbonitrile; With water; sodium hydroxide; at 120 ℃;

With hydrogenchloride; In water; pH=3;

Reference yield:

5-methylpicolinonitrile (1620-77-5) → 6-bromo-5-methyl-pyridine-2-carboxylic acid (1211516-25-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 - 60 °C

2.1: phosphorus(V) oxybromide / 1 h / 100 °C

3.1: sodium hydroxide; water / 120 °C

3.2: pH 3

With water; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; phosphorus(V) oxybromide; In dichloromethane;

Reference yield:

2-fluoro-5-methylpyridine (2369-19-9) → 6-bromo-5-methyl-pyridine-2-carboxylic acid (1211516-25-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide / 48 h / 150 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 - 60 °C

3.1: phosphorus(V) oxybromide / 1 h / 100 °C

4.1: sodium hydroxide; water / 120 °C

4.2: pH 3

With water; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; phosphorus(V) oxybromide; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

5-methylpicolinonitrile

2-fluoro-5-methylpyridine

6-bromo-5-methylpyridine-2-carbonitrile

2-cyano-5-methylpyridine 1-oxide

Downstream raw materials:

6-(3-chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid

Refernces

• 1、 -. "PYRIDIN- 2 -AMIDES USEFUL AS CB2 AGONISTS". . . Retrieved 2013/02/27.