4-ethynyl-2-Methylpyridine

Base Information

• Chemical Name: 4-ethynyl-2-Methylpyridine
• CAS No.: 30413-56-0
• Molecular Formula: C8H7N
• Molecular Weight: 117.15
• Hs Code.: 2933399990
• Mol file: 30413-56-0.mol

Synonyms:4-ethynyl-2-Methylpyridine;4-Ethynyl-2-picoline, (2-Methylpyridin-4-yl)acetylene

Chemical Property of 4-ethynyl-2-Methylpyridine

Chemical Property:

• Boiling Point: 188.9±28.0 °C(Predicted)
• PKA: 4.84±0.10(Predicted)
• PSA: 12.89000
• Density: 1.00±0.1 g/cm3(Predicted)
• LogP: 1.37130

Purity/Quality:

98%, ^*data from raw suppliers

4-Ethynyl-2-methyl-pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ethynyl-2-Methylpyridine

There total 3 articles about 4-ethynyl-2-Methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-methyl-4-((trimethylsilyl)ethynyl)pyridine (761426-51-1) → 4-ethynyl-2-methyl-pyridine (30413-56-0)

Guidance literature:

With potassium carbonate; In methanol; at 60 ℃; for 2h;

Reference yield: 43.3%

4-bromo-2-methylpyridine (22282-99-1) + trimethylsilylacetylene (1066-54-2) → 4-ethynyl-2-methyl-pyridine (30413-56-0)

Guidance literature:

4-bromo-2-methylpyridine; trimethylsilylacetylene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

Reference yield:

4-bromo-2-methylpyridine (22282-99-1) → 4-ethynyl-2-methyl-pyridine (30413-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / 16 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;

upstream raw materials:

2-methyl-4-((trimethylsilyl)ethynyl)pyridine

4-bromo-2-methylpyridine

trimethylsilylacetylene

Downstream raw materials:

4-[(3-bromo-4-fluorophenyl)ethynyI]-2-methyIpyridine

C₂₁H₁₃Cl₂N₃O₂

Refernces

• 1、 Malamas, Michael S.,Barnes, Keith,Johnson, Matthew,Hui, Yu,Zhou, Ping,Turner, Jim,Hu, Yun,Wagner, Erik,Fan, Kristi,Chopra, Rajiv,Olland, Andrea,Bard, Jonathan,Pangalos, Menelas,Reinhart, Peter,Robichaud, Albert J.. "Di-substituted pyridinyl aminohydantoins as potent and highly selective human β-secretase (BACE1) inhibitors". scheme or table. p. 630 - 639. Retrieved 2010/04/26.
• 2、 -. "NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES". Page/Page column 188-189. . Retrieved 2008/12/06.