N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine

Base Information

• Chemical Name: N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine
• CAS No.: 500131-50-0
• Molecular Formula: C12H17F2N
• Molecular Weight: 213.27
• Hs Code.: 2921499090
• Mol file: 500131-50-0.mol

Synonyms:N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine;N,N-Diethyl-α,α-difluoro-3-ethylbenzylaMine;DFMBA;N,N-Diethyl-α,α-difluoro-3-MethylbenzylaMine

Chemical Property of N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine

Chemical Property:

• Vapor Pressure: 0.0533mmHg at 25°C
• Boiling Point: 234.3°C at 760 mmHg
• PKA: 1.74±0.70(Predicted)
• Flash Point: 96℃
• PSA: 3.24000
• Density: 1.03g/cm³
• LogP: 3.38610

Purity/Quality:

99% ^*data from raw suppliers

N-[difluoro-(3-methylphenyl)methyl]-N-ethylethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine

There total 4 articles about N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N,N-Diethyl-3-methylbenzamide (134-62-3,94271-03-1) → N,N-diethyl-α,α-difluoro-(meta-methylbenzyl)amine (500131-50-0)

Guidance literature:

N,N-Diethyl-3-methylbenzamide; With oxalyl dichloride; In dichloromethane; at 40 ℃; for 2h;

With triethylamine tris(hydrogen fluoride); triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.jfluchem.2005.02.004

Reference yield: 81.0%

→ N,N-diethyl-α,α-difluoro-(meta-methylbenzyl)amine (500131-50-0)

Guidance literature:

Reference yield: 60.0%

N,N-diethyl-αlpha;-chloro-meta-toluylamidinum chloride (500131-49-7) → N,N-diethyl-α,α-difluoro-(meta-methylbenzyl)amine (500131-50-0)

Guidance literature:

With potassium fluoride; In acetonitrile; for 18h; Heating / reflux;

upstream raw materials:

N,N-Diethyl-3-methylbenzamide

N,N-diethyl-αlpha;-chloro-meta-toluylamidinum chloride

Downstream raw materials:

3-hydroxy-2,2-dimethylpropan-1-yl 3-methylbenzoate

6-deoxy-6-fluoro-1,2:3,4-di-O-isopropylidene-α-D-galctopyranose

N,N-Diethyl-3-methylbenzamide

5-(3-methylphenyl)-1-aza-4,6-dioxabicyclo[3.3.0]octane

Refernces

• 1、 Fukuhara, Tsuyoshi,Hasegawa, Chihiro,Hara, Shoji. "A facile synthesis of oxazolines, thiazolines, and imidazolines using α,α-difluoroalkylamines". . p. 1528 - 1534. Retrieved 2008/02/05.
• 2、 -. "PROCESS FOR PRODUCING α,α-DIFLUOROAMINE". Page/Page column 13. . Retrieved 2008/06/13.