5H-INDEN-5-ONE, 1-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-1,2,3,6,7,7A-HEXAHYDRO-4,7A-DIMETHYL-, (1S,7AS)- (9CI)

Base Information

Chemical Name:5H-INDEN-5-ONE, 1-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-1,2,3,6,7,7A-HEXAHYDRO-4,7A-DIMETHYL-, (1S,7AS)- (9CI)
CAS No.:678159-99-4
Molecular Formula:C27H34O2Si
Molecular Weight:418.651
Hs Code.:
Mol file:678159-99-4.mol

Synonyms:5H-INDEN-5-ONE, 1-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-1,2,3,6,7,7A-HEXAHYDRO-4,7A-DIMETHYL-, (1S,7AS)- (9CI);(1S,7AS)-1-(TERT-BUTYLDIPHENYLSILYLOXY)-4,7A-DIMETHYL-2,3,7,7A-TETRAHYDRO-1H-INDEN-5(6H)-ONE

Suppliers and Price of 5H-INDEN-5-ONE, 1-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-1,2,3,6,7,7A-HEXAHYDRO-4,7A-DIMETHYL-, (1S,7AS)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(1S,7AS)-1-(TERT-BUTYLDIPHENYLSILYLOXY)-4,7A-DIMETHYL-2,3,7,7A-TETRAHYDRO-1H-INDEN-5(6H)-ONE 95.00%
5MG
$ 498.70

Total 1 raw suppliers

Chemical Property of 5H-INDEN-5-ONE, 1-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-1,2,3,6,7,7A-HEXAHYDRO-4,7A-DIMETHYL-, (1S,7AS)- (9CI)

Chemical Property:

Vapor Pressure:9.3E-10mmHg at 25°C
Boiling Point:490.2°C at 760 mmHg
Flash Point:207.9°C
PSA：26.30000
Density:1.07g/cm³
LogP:5.41110

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

(1S,7AS)-1-(TERT-BUTYLDIPHENYLSILYLOXY)-4,7A-DIMETHYL-2,3,7,7A-TETRAHYDRO-1H-INDEN-5(6H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5H-INDEN-5-ONE, 1-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-1,2,3,6,7,7A-HEXAHYDRO-4,7A-DIMETHYL-, (1S,7AS)- (9CI)

There total 5 articles about 5H-INDEN-5-ONE, 1-[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]-1,2,3,6,7,7A-HEXAHYDRO-4,7A-DIMETHYL-, (1S,7AS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 212953-00-9
(1S,7aS)-(+)-1-hydroxy-4,7a-dimethyl-2,3,7,7a-tetrahydro-1H-indene-5⁽⁶⁾-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 678159-99-4
(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 25 ℃; for 4h;
DOI:10.1002/anie.200352868

Reference yield:

: 33878-96-5
(7aS)-(+)-4,7a-dimethyl-2,3,7,7a-tetrahydro-1H-indene-1,5(6H)-dione

: 678159-99-4
(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / NaBH₄ / methanol / 0.5 h / 0 °C

2: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.200500513

Reference yield:

: 765-69-5
2-Methylcyclopentane-1,3-dione

: 678159-99-4
(1S,7aS)-1-(tert-Butyl-diphenyl-silanyloxy)-4,7a-dimethyl-1,2,3,6,7,7a-hexahydro-inden-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / Et₃N / ethyl acetate / 12 h / 25 °C

2: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C

3: 97 percent / NaBH₄ / methanol / 0.5 h / 0 °C

4: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; L-phenylalanine; (1S)-10-camphorsulfonic acid; triethylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 2: asymmetric Robinson annulation;
DOI:10.1002/chem.200500513