6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

Base Information

• Chemical Name: 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one
• CAS No.: 1190866-02-4
• Molecular Formula: C₁₃H₁₄BrNO
• Molecular Weight: 280.164
• Hs Code.: 2933990090
• Mol file: 1190866-02-4.mol

Synonyms:6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

Chemical Property of 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

Chemical Property:

• PSA: 29.10000
• LogP: 3.74110

Purity/Quality:

99% ^*data from raw suppliers

6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6''-Bromo-1'',2''-dihydrospiro[cyclohexane-1,3''-indole]-2''-one is used in preparation of Dibenzo[b,f][1,4]thiazepinecarboxamides as hepatitis B core protein modulators.

Technology Process of 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

There total 6 articles about 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.6%

1,5-dibromo-pentane (111-24-0) + 6-bromo-2,3-dihydro-1H-indole-2-one (99365-40-9) → 6’-bromospiro[cyclohexane-1,3’-indolin]-2’-one (1190866-02-4)

Guidance literature:

6-bromo-2,3-dihydro-1H-indole-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

1,5-dibromo-pentane; In tetrahydrofuran; at -78 - 20 ℃; for 12.5h;

Reference yield: 24.0%

→ 6’-bromospiro[cyclohexane-1,3’-indolin]-2’-one (1190866-02-4)

Guidance literature:

Reference yield:

1,5-diiodopentane (628-77-3) + 6-bromo-2,3-dihydro-1H-indole-2-one (99365-40-9) → 6’-bromospiro[cyclohexane-1,3’-indolin]-2’-one (1190866-02-4)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.bmcl.2011.05.114

upstream raw materials:

1,5-diiodopentane

6-bromo-2,3-dihydro-1H-indole-2-one

(4-bromo-2-nitrophenyl)acetic acid

4-Bromo-1-fluoro-2-nitrobenzene