6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

Base Information

Chemical Name:6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one
CAS No.:1190866-02-4
Molecular Formula:C₁₃H₁₄BrNO
Molecular Weight:280.164
Hs Code.:2933990090
Mol file:1190866-02-4.mol

Synonyms:6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

Suppliers and Price of 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one >95%
500mg
$ 425.00

Matrix Scientific
6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one >95%
1g
$ 516.00

Crysdot
6'-Bromospiro[cyclohexane-1,3'-indolin]-2'-one 95+%
1g
$ 511.00

Chemenu
6''-Bromospiro[cyclohexane-1,3''-indolin]-2''-one 95%
1g
$ 482.00

AK Scientific
6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one
500mg
$ 623.00

Total 4 raw suppliers

Chemical Property of 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

Chemical Property:

PSA：29.10000
LogP:3.74110

Purity/Quality:

98% ^*data from raw suppliers

6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 6''-Bromo-1'',2''-dihydrospiro[cyclohexane-1,3''-indole]-2''-one is used in preparation of Dibenzo[b,f][1,4]thiazepinecarboxamides as hepatitis B core protein modulators.

Technology Process of 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one

There total 6 articles about 6'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.6%

: 111-24-0
1,5-dibromo-pentane

: 99365-40-9
6-bromo-2,3-dihydro-1H-indole-2-one

: 1190866-02-4
6’-bromospiro[cyclohexane-1,3’-indolin]-2’-one

Guidance literature:: 6-bromo-2,3-dihydro-1H-indole-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

1,5-dibromo-pentane; In tetrahydrofuran; at -78 - 20 ℃; for 12.5h;

Reference yield: 24.0%

: 1190866-02-4
6’-bromospiro[cyclohexane-1,3’-indolin]-2’-one

Guidance literature:

Reference yield:

: 628-77-3
1,5-diiodopentane

: 99365-40-9
6-bromo-2,3-dihydro-1H-indole-2-one

: 1190866-02-4
6’-bromospiro[cyclohexane-1,3’-indolin]-2’-one

Guidance literature:: With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2011.05.114