(S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3

Base Information

• Chemical Name: (S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3
• CAS No.: 156451-08-0
• Molecular Formula: C13H12D3NO3
• Molecular Weight: 236.281585334
• Mol file: 156451-08-0.mol

Synonyms:(S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3;(+)-4-Benzyl-3-propionyl-2-oxazolidinone-d3;(4S)-3-(1-Oxopropyl)-4-(phenylMethyl)-2-oxazolidinone-d3;(4S)-4-Benzyl-3-propanoyloxazolidin-2-one-d3;(4S)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one-d3;(S)-N-Propi

Chemical Property of (S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3

Chemical Property:

• PSA: 46.61000
• LogP: 1.92440
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

(S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of labelled Albaconazole.

Technology Process of (S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3

There total 2 articles about (S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

iodomethane-d3 (865-50-9) + (S)-3-acetyl-4-benzyloxazolidin-2-one (132836-66-9) → C13H12(2)H3NO3 (156451-08-0)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(00)76541-5

Reference yield:

(S)-4-Benzyl-2-oxazolidinone (90719-32-7) → C13H12(2)H3NO3 (156451-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / nBuLi / tetrahydrofuran / 0 °C

2: 74 percent / NaN(SiMe₃)2, DMPU / tetrahydrofuran / -78 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)76541-5

Reference yield:

(S)-(E)-2-methyl-hex-4-enal (104372-55-6,519002-37-0) + C13H12(2)H3NO3 (156451-08-0) → C20H24(2)H3NO4 (156555-98-5)

Guidance literature:

With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 2.) CH₂Cl₂, -78 deg C;

DOI:10.1016/S0040-4039(00)76541-5

upstream raw materials:

iodomethane-d3

(S)-3-acetyl-4-benzyloxazolidin-2-one

(S)-4-Benzyl-2-oxazolidinone

Downstream raw materials:

C₂₀H₂₄⁽²⁾H₃NO₄