benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-

Base Information

Chemical Name:benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-
CAS No.:1391052-76-8
Molecular Formula:C13H8Cl2F2N2O3
Molecular Weight:349.121
Hs Code.:
Mol file:1391052-76-8.mol

Synonyms:benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-;N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)-3-hydroxybenzaMide;RofluMilast IMp.E;N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide;Roflumilast Impurity E

Suppliers and Price of benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-O-DecyclopropylRoflumilast
100mg
$ 1320.00

DC Chemicals
RoflumilastImpurityE >98%
10 mg
$ 400.00

DC Chemicals
RoflumilastImpurityE >98%
5 mg
$ 264.00

ChemScene
RoflumilastImpurityE
10mg
$ 600.00

ChemScene
RoflumilastImpurityE
1mg
$ 132.00

ChemScene
RoflumilastImpurityE
5mg
$ 396.00

Chemenu
N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-hydroxybenzamide 97%
10mg
$ 327.00

Biorbyt Ltd
Roflumilast Impurity E E
10 mg
$ 615.40

Biorbyt Ltd
Roflumilast Impurity E E
5 mg
$ 538.90

Total 16 raw suppliers

Chemical Property of benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-

Chemical Property:

Boiling Point:397.4±42.0 °C(Predicted)
PKA:7.59±0.35(Predicted)
PSA：71.45000
Density:1.593±0.06 g/cm3(Predicted)
LogP:4.02070

Purity/Quality:

98% ^*data from raw suppliers

3-O-DecyclopropylRoflumilast ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses O-Decyclopropyl Roflumilast is an impurity of Roflumilast (R639700).

Technology Process of benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-

There total 6 articles about benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.9%

: N-(3,5-dichloro-4-pyridyl)-4-(difluoromethoxy)-3-formylbenzamide

: 1391052-76-8
BYK₂₀₈₃₉

Guidance literature:: With sulfuric acid; dihydrogen peroxide; In methanol; at 20 - 30 ℃; for 10h; Reagent/catalyst;

Reference yield:

: 3-(benzyloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

: 1391052-76-8
BYK₂₀₈₃₉

Guidance literature:: With trifluoroacetic acid; at 80 ℃; for 1h;

Reference yield:

: 151103-08-1
4-difluoromethoxy-3-hydroxybenzaldehyde

: 1391052-76-8
BYK₂₀₈₃₉

Guidance literature:: Multi-step reaction with 3 steps

1.1: aminosulfonic acid; sodium chlorite / acetonitrile; water / 0 - 30 °C

2.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 3 h / 90 °C / Reflux

3.1: sodium hydride / acetonitrile / 2 h / 0 - 5 °C

3.2: 1.5 h / 0 - 15 °C

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; N,N-dimethyl-formamide; In water; toluene; acetonitrile;
DOI:10.1007/s11164-012-0823-3