7-BENZYL-2,7-DIAZASPIRO[4,4]NONAN-3-ONE

Base Information

• Chemical Name: 7-BENZYL-2,7-DIAZASPIRO[4,4]NONAN-3-ONE
• CAS No.: 909723-04-2
• Molecular Formula: C₁₄H₁₈N₂O
• Molecular Weight: 230.31
• Hs Code.: 2933990090
• Mol file: 909723-04-2.mol

Synonyms:7-BENZYL-2,7-DIAZASPIRO[4,4]NONAN-3-ONE;2,7-Diazaspiro[4.4]nonan-3-one, 7-(phenylMethyl)-

Chemical Property of 7-BENZYL-2,7-DIAZASPIRO[4,4]NONAN-3-ONE

Chemical Property:

• Vapor Pressure: 3.26E-07mmHg at 25°C
• Boiling Point: 418.5ºC at 760 mmHg
• PKA: 16.26±0.20(Predicted)
• Flash Point: 206.9ºC
• PSA: 35.83000
• Density: 1.17g/cm3
• LogP: 1.61240
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

7-Benzyl-2,7-diazaspiro[4.4]nonan-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BENZYL-2,7-DIAZASPIRO[4,4]NONAN-3-ONE

There total 2 articles about 7-BENZYL-2,7-DIAZASPIRO[4,4]NONAN-3-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl [1-benzyl-3-(nitromethyl)pyrrolidin-3-yl]acetate (935744-97-1) → 7-benzyl-2,7-diazaspiro[4.4]nonan-3-one (909723-04-2)

Guidance literature:

With hydrogen; nickel; In ethanol; at 30 ℃; for 24h; under 2068.65 Torr;

Reference yield: 59.0%

C16H22N2O4 (909723-03-1) → 7-benzyl-2,7-diazaspiro[4.4]nonan-3-one (909723-04-2)

Guidance literature:

With ammonia; hydrogen; RaNi; In methanol; at 20 ℃; for 18h; under 2250.23 Torr;

Reference yield:

7-benzyl-2,7-diazaspiro[4.4]nonan-3-one (909723-04-2) → tert-butyl 7-(5-(2-(diisopropylcarbamoyl)-4-fluorophenoxy)pyrimidin-4-yl)-3-(4-fluorobenzyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate

Guidance literature:

Multi-step reaction with 5 steps

1.1: dmap / dichloromethane / 48 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 1 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: 1 h / 20 °C

3.3: 4 h / 20 °C

4.1: hydrogen; 5% Pd(OH)₂/C / methanol / 40 h / 20 °C

5.1: isopropyl alcohol / 2 h / 120 °C / Microwave irradiation

With dmap; 5% Pd(OH)₂/C; hydrogen; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; isopropyl alcohol;

upstream raw materials:

C₁₆H₂₂N₂O₄

methyl [1-benzyl-3-(nitromethyl)pyrrolidin-3-yl]acetate

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