Technology Process of (S)-(FLUOROMETHYL)-BENZENEETHANAMINE HYDROCHLORIDE
There total 4 articles about (S)-(FLUOROMETHYL)-BENZENEETHANAMINE HYDROCHLORIDE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N,N-diallyl-1-fluoro-3-phenylpropan-2-amine;
With
tris-(dibenzylideneacetone)dipalladium(0); thiosalicilyc acid; 1,4-di(diphenylphosphino)-butane;
In
tetrahydrofuran;
at 60 ℃;
for 5h;
Inert atmosphere;
With
hydrogenchloride; ethyl acetate;
In
tetrahydrofuran; water;
Inert atmosphere;
DOI:10.1021/acs.joc.5b01714
- Guidance literature:
-
With
pyridine; hydrogenchloride; potassium fluoride; hydrogen fluoride;
at 60 ℃;
for 120h;
DOI:10.1016/S0022-1139(00)85218-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 20 °C
2.1: trifluoromethylsulfonic anhydride / dichloromethane / 1 h / 20 °C / Inert atmosphere
2.2: 0.02 h / 20 °C / Inert atmosphere
2.3: 2 h / 90 °C / Inert atmosphere
3.1: 1,4-di(diphenylphosphino)-butane; tris-(dibenzylideneacetone)dipalladium(0); thiosalicilyc acid / tetrahydrofuran / 5 h / 60 °C / Inert atmosphere
3.2: Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); trifluoromethylsulfonic anhydride; thiosalicilyc acid; potassium carbonate; 1,4-di(diphenylphosphino)-butane;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/acs.joc.5b01714
