5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 1000341-42-3
• Molecular Formula: C₁₁H₁₀N₂O₅
• Molecular Weight: 250.211
• Mol file: 1000341-42-3.mol

Synonyms:5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER;methyl 5-methoxy-7-nitro-1H-indole-2-carboxylate

Chemical Property of 5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 97.14000
• LogP: 2.39450

Purity/Quality:

99% ^*data from raw suppliers

5-Methoxy-7-nitro-2-indolecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER

There total 4 articles about 5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

→ 5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester (1000341-42-3)

Guidance literature:

Reference yield:

C11H13N3O5 → 5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester (1000341-42-3)

Guidance literature:

With polyphosphoric acid; at 70 ℃;

DOI:10.1016/j.bmcl.2015.12.055

Reference yield:

4-methoxy-2-nitroaniline (96-96-8) → 5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester (1000341-42-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite

2: sodium acetate

3: polyphosphoric acid / 70 °C

With hydrogenchloride; sodium acetate; sodium nitrite;

DOI:10.1016/j.bmcl.2015.12.055

upstream raw materials:

4-methoxy-2-nitroaniline

4-methoxy-2-nitrophenylhydrazine

Downstream raw materials:

5-methoxy-7-nitro-1H-indole-2-carboxylic acid

Refernces

• 1、 -. "GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT". Page/Page column 21. . Retrieved 2010/11/03.
• 2、 -. "GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT". Page/Page column 71. . Retrieved 2009/07/25.