1-BroMo-3-(2,2-diethoxy-ethoxy)-benzene

Base Information

• Chemical Name: 1-BroMo-3-(2,2-diethoxy-ethoxy)-benzene
• CAS No.: 204452-94-8
• Molecular Formula: C12H17BrO3
• Molecular Weight: 289.169
• Mol file: 204452-94-8.mol

Synonyms:1-BroMo-3-(2,2-diethoxy-ethoxy)-benzene

Chemical Property of 1-BroMo-3-(2,2-diethoxy-ethoxy)-benzene

Chemical Property:

• PSA: 27.69000
• LogP: 3.22700

Purity/Quality:

98% ^*data from raw suppliers

1-Bromo-3-(2,2-diethoxy-ethoxy)-benzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BroMo-3-(2,2-diethoxy-ethoxy)-benzene

There total 2 articles about 1-BroMo-3-(2,2-diethoxy-ethoxy)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Bromophenol (591-20-8) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-(3-bromophenoxy)acetaldehyde diethyl acetal (204452-94-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 120 ℃; Cooling with ice;

Reference yield: 93.0%

→ 2-(3-bromophenoxy)acetaldehyde diethyl acetal (204452-94-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 160 ℃; for 3h; Inert atmosphere;

Reference yield: 85.0%

2-(3-bromophenoxy)acetaldehyde diethyl acetal (204452-94-8) → 2-(3-bromo-5-(2,2-diethoxyethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1392146-19-8)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tert-butyl methyl ether; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1007/s11164-012-0725-4

upstream raw materials:

3-Bromophenol

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

benzofuran-4-carboxaldehyde

benzofuran-6-carboxaldehyde

6-bromo-benzofuran

4-bromo-1-benzofuran

Refernces

• 1、 -. "Pyrimidine or pyrazino five-membered heterocyclic compound and applications thereof". Paragraph 0214-0218. . Retrieved 2020/02/14.
• 2、 -. "IMIDAZO[1,2-C]PYRIMIDINE DERIVATIVES AS PRC2 INHIBITORS FOR TREATING CANCER". Paragraph 0173-0174. . Retrieved 2020/12/29.