T-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE

Base Information

Chemical Name:T-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE
CAS No.:324788-98-9
Molecular Formula:C19H20FNO4
Molecular Weight:345.371
Hs Code.:2924299090
Mol file:324788-98-9.mol

Synonyms:T-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE;tert-Butyl 4-(Z-amino)-2-fluorobenzoate

Suppliers and Price of T-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
tert-Butyl 4-(Z-amino)-2-fluorobenzoate
1g
$ 1340.00

American Custom Chemicals Corporation
TERT-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE 95.00%
5MG
$ 503.18

Total 2 raw suppliers

Chemical Property of T-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE

Chemical Property:

Boiling Point:428.6±45.0 °C(Predicted)
PKA:12.44±0.70(Predicted)
PSA：64.63000
Density:1.227±0.06 g/cm3(Predicted)
LogP:4.60270

Purity/Quality:

95% ^*data from raw suppliers

tert-Butyl 4-(Z-amino)-2-fluorobenzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of T-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE

There total 5 articles about T-BUTYL-4-N-Z-AMINO-2-FLUORO-BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 140373-77-9
tert-butyl 2-fluoro-4-aminobenzoate

: 324788-98-9
tert-butyl 4-benzyloxycarbonylamino-2-fluoro-benzoate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 50 ℃; for 19h;

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 324788-98-9
tert-butyl 4-benzyloxycarbonylamino-2-fluoro-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: CrO₃; AcOH

2: SOCl₂ / CH₂Cl₂

3: tetrahydrofuran

4: Fe; aq. NH₄Cl

5: pyridine / CH₂Cl₂

With pyridine; chromium(VI) oxide; thionyl chloride; iron; ammonium chloride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.07.021

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 324788-98-9
tert-butyl 4-benzyloxycarbonylamino-2-fluoro-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / CH₂Cl₂

2: tetrahydrofuran

3: Fe; aq. NH₄Cl

4: pyridine / CH₂Cl₂

With pyridine; thionyl chloride; iron; ammonium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.07.021