2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide

Base Information

• Chemical Name: 2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide
• CAS No.: 944450-78-6
• Molecular Formula: C10H9BrN2O.BrH
• Molecular Weight: 334.01
• Hs Code.: 2933990090
• Mol file: 944450-78-6.mol

Synonyms:2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide;5-(Bromoacetyl)-1-methyl-1H-benzimidazole hydrobromide;2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethan-1-one hydrobromide;2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethan-1-one hydrobromide, 5-(2-Bromoethanoyl)-1-methyl-1H-benzimidazole hydrobromide

Chemical Property of 2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide

Chemical Property:

• Vapor Pressure: 3.4E-07mmHg at 25°C
• Melting Point: 196-196.5°C
• Boiling Point: 408.9°C at 760 mmHg
• Flash Point: 201.1°C
• PSA: 34.89000
• LogP: 3.10900

Purity/Quality:

98%Min ^*data from raw suppliers

5-(Bromoacetyl)-1-methyl-1H-benzimidazole hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide

There total 3 articles about 2-Bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(1-methyl-1H-benzo[d]imidazol-5-yl)ethan-1-one (265107-91-3) → 2-bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide (944450-78-6)

Guidance literature:

With bromine; In 1,4-dioxane; hydrogen bromide;

Reference yield:

N-methoxy-N,1-dimethyl-1H-benzo[d]imidazole-5-carboxamide (1378023-17-6) → 2-bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide (944450-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: MeMgBr / tetrahydrofuran

2: bromine / 1,4-dioxane; hydrogen bromide

With MeMgBr; bromine; In tetrahydrofuran; 1,4-dioxane; hydrogen bromide;

Reference yield:

1-methyl-1H-benzoimidazole-5-carbonyl chloride.HCl (906352-57-6) → 2-bromo-1-(1-methyl-1H-benzimidazol-5-yl)ethanone hydrobromide (944450-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane; water

2: MeMgBr / tetrahydrofuran

3: bromine / 1,4-dioxane; hydrogen bromide

With MeMgBr; bromine; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; hydrogen bromide;

upstream raw materials:

N-methoxy-N,1-dimethyl-1H-benzo[d]imidazole-5-carboxamide

1-(1-methyl-1H-benzo[d]imidazol-5-yl)ethan-1-one

1-methyl-1H-benzoimidazole-5-carbonyl chloride.HCl

Downstream raw materials:

(5-Fluoro-2-methoxy-phenyl)-[4-(1-methyl-1H-benzoimidazol-5-yl)-thiazol-2-yl]-amine

Refernces