BENZOIC ACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYL ESTER

Base Information

• Chemical Name: BENZOIC ACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYL ESTER
• CAS No.: 17746-77-9
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Mol file: 17746-77-9.mol

Synonyms:BENZOIC ACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYL ESTER

Chemical Property of BENZOIC ACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYL ESTER

Chemical Property:

• PSA: 46.53000
• LogP: 2.24970

Purity/Quality:

BENZOICACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOIC ACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYL ESTER

There total 2 articles about BENZOIC ACID,3-BROMO-2-HYDROXY-5-METHYL-,METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 6-hydroxy-m-toluate (22717-57-3) → methyl 3-bromo-2-hydroxy-5-methylbenzoate (17746-77-9)

Guidance literature:

With bromine; In chloroform; at 20 ℃; for 4.5h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-bromo-5-methylsalicylic acid (17746-75-7) → methyl 3-bromo-2-hydroxy-5-methylbenzoate (17746-77-9)

Guidance literature:

DOI:10.1039/j39680000499

Reference yield: 91.0%

methyl 3-bromo-2-hydroxy-5-methylbenzoate (17746-77-9) → 2-bromo-6-(hydroxymethyl)-4-methyl-phenol (43135-49-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1021/jm800853p

upstream raw materials:

diazomethane

3-bromo-5-methylsalicylic acid

methyl 6-hydroxy-m-toluate

Downstream raw materials:

2-bromo-6-(hydroxymethyl)-4-methyl-phenol

(E)-1-(3-bromo-2-hydroxy-5-methylphenyl)-3-(2-chloro-6-ethoxyquinolin-3-yl)prop-2-en-1-one

Refernces

• 1、 Gisch, Nicolas,Balzarini, Jan,Meier, Chris. "Studies on enzyme-cleavable dialkoxymethyl-cycloSaligenyl-2′, 3′-dideoxy-2′,3′-didehydrothymidine monophosphates". experimental part. p. 6752 - 6760. Retrieved 2009/11/30.