(4aα,4bα,8aα,8bα)-4a,4b,8a,8b-Tetrahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,4,5,7(1H,3H,6H,8H)-tetrone

Base Information

• Chemical Name: (4aα,4bα,8aα,8bα)-4a,4b,8a,8b-Tetrahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,4,5,7(1H,3H,6H,8H)-tetrone
• CAS No.: 13375-99-0
• Molecular Formula: C8H8N4O4
• Molecular Weight: 224.17
• Mol file: 13375-99-0.mol

Synonyms:(4aα,4bα,8aα,8bα)-4a,4b,8a,8b-Tetrahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,4,5,7(1H,3H,6H,8H)-tetrone;cis-syn-Uracil dimer

Chemical Property of (4aα,4bα,8aα,8bα)-4a,4b,8a,8b-Tetrahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,4,5,7(1H,3H,6H,8H)-tetrone

Chemical Property:

• PSA: 116.40000
• LogP: -1.03640

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aα,4bα,8aα,8bα)-4a,4b,8a,8b-Tetrahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,4,5,7(1H,3H,6H,8H)-tetrone

There total 10 articles about (4aα,4bα,8aα,8bα)-4a,4b,8a,8b-Tetrahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,4,5,7(1H,3H,6H,8H)-tetrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[(2R,3S,5R)-3-benzyloxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (208330-05-6) → hexahydro-cyclobuta[1,2-d;4,3-d']dipyrimidine-2,4,5,7-tetraone (4840-71-5,13375-99-0,20714-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 percent / acetone / 1.5 h / Irradiation

2: HCl, H₂O / 0.5 h / 100 °C

With hydrogenchloride; water; In acetone;

DOI:10.1002/(SICI)1521-3765(19980416)4:4<642::AID-CHEM642>3.0.CO;2-K

Reference yield:

C31H38N4O11 (208330-07-8) → hexahydro-cyclobuta[1,2-d;4,3-d']dipyrimidine-2,4,5,7-tetraone (4840-71-5,13375-99-0,20714-60-7)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 0.5h; Yield given;

DOI:10.1002/(SICI)1521-3765(19980416)4:4<642::AID-CHEM642>3.0.CO;2-K

Reference yield:

C31H38N4O11 (208330-06-7) → hexahydro-cyclobuta[1,2-d;4,3-d']dipyrimidine-2,4,5,7-tetraone (13375-99-0)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 0.5h; Yield given;

DOI:10.1002/(SICI)1521-3765(19980416)4:4<642::AID-CHEM642>3.0.CO;2-K

upstream raw materials:

C₃₁H₃₈N₄O₁₁

C₃₁H₃₈N₄O₁₁

2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[(2R,3S,5R)-3-benzyloxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

uracil