Glycine,N-(N-L-gamma-glutamyl-D-cysteinyl)-

Base Information

• Chemical Name: Glycine,N-(N-L-gamma-glutamyl-D-cysteinyl)-
• CAS No.: 128960-77-0
• Molecular Formula: C10H17N3O6S
• Molecular Weight: 307.327
• DSSTox Substance ID: DTXSID301303707
• Mol file: 128960-77-0.mol

Synonyms:128960-77-0;Glycine,N-(N-L-gamma-glutamyl-D-cysteinyl)-;(2S)-2-amino-5-[[(2S)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;glytathione;SCHEMBL7469803;DTXSID301303707;L-gamma-Glutamyl-D-cysteinylglycine;EN300-27126232;(2S)-2-amino-4-{[(1S)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid

Chemical Property of Glycine,N-(N-L-gamma-glutamyl-D-cysteinyl)-

Chemical Property:

• PSA: 197.62000
• LogP: -0.72400
• XLogP3: -4.5
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 307.08380644
• Heavy Atom Count: 20
• Complexity: 389

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
• Isomeric SMILES: C(CC(=O)N[C@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N

Technology Process of Glycine,N-(N-L-gamma-glutamyl-D-cysteinyl)-

There total 2 articles about Glycine,N-(N-L-gamma-glutamyl-D-cysteinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glutathione disulfide (27025-41-8,40055-98-9,121-24-4,87140-29-2) + D-2-methyl-3-mercaptopropionyl-l-prolin (62571-86-2,63250-36-2,64838-54-6,112243-88-6,112243-90-0,119238-52-7) → glutathione (128960-77-0) + captopril disulfide (64838-57-9) + captopril-glutathione mixed disulfide (78636-30-3,103833-76-7)

Guidance literature:

With potassium chloride; edetate disodium; tert-butyl alcohol; In water-d2; Equilibrium constant;

DOI:10.1139/v85-006

Reference yield:

→ 2-(4-ammonio-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl (70-18-8,76946-74-2,108457-42-7,128960-77-0,148102-19-6)

Guidance literature:

Glutathion, Ce⁴⁺;

DOI:10.1016/0022-2364(69)90047-X

Reference yield: 94.0%

[Pt(tris(2-diphenylphosphinoethyl)amine)Cl]Cl*4H2O + glutathione (70-18-8,76946-74-2,108457-42-7,128960-77-0,148102-19-6) → PtN(C2H4P(C6H5)2)3(O2CCHNH3C2H4CONHCHCH2SCONHCH2CO2)*2H2O=PtN(C2H4P(C6H5)2)3(O2CCHNH3C2H4CONHCHCH2SCONHCH2CO2)*2H2O

Guidance literature:

In methanol; water; to a soln. of aminoacid in water was added dropwise to a soln. of complex in water, the mixt. was stirred for 48 h at ambient temp.; filtered, lyophilised, washed with ether, dried in vac.; elem. anal.;

DOI:10.1016/S0020-1693(02)00813-7

upstream raw materials:

glutathione disulfide

D-2-methyl-3-mercaptopropionyl-l-prolin

Downstream raw materials:

(7E,9Z,11Z,14Z)-(5S,6R)-6-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid

(7E,9Z,11Z,14Z)-(5R,6S)-6-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid

5(S)-hydroxy-6(R)-glutathionyl-7,9-E-11,14-Z-eicosatetraenoic acid

leukotriene C4