Radiatinol methyl ether

Base Information

• Chemical Name: Radiatinol methyl ether
• CAS No.: 19937-86-1
• Molecular Formula: C11H12O4
• Molecular Weight: 208.2106
• Mol file: 19937-86-1.mol

Synonyms:1-(7-methoxy-2H-benzo[d]1,3-dioxolen-5-yl)propan-1-one;1-(7-Methoxy-1,3-benzodioxol-5-yl)-1-propanone;

Chemical Property of Radiatinol methyl ether

Chemical Property:

• Vapor Pressure: 0.000146mmHg at 25°C
• Melting Point: 89-90 °C
• Boiling Point: 332.5°Cat760mmHg
• Flash Point: 147.6°C
• PSA: 44.76000
• Density: 1.205g/cm³
• LogP: 2.01660

Purity/Quality:

99% ^*data from raw suppliers

Crocatone ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Radiatinol methyl ether

There total 9 articles about Radiatinol methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

jones' reagent + ethylmagnesium bromide (925-90-6) + 3-methoxy-4,5-methylenedioxybenzaldehyde (5780-07-4) + isopropyl alcohol (67-63-0,8013-70-5) → (E)-3-(1H-indol-3-yl)-1-(7-methoxybenzo[d][1,3]dioxol-5-yl)-2-methylprop-2-en-1-one + 1-(7-methoxy-benzo[1,3]dioxol-5-yl)-propan-1-one (19937-86-1)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; acetone;

Reference yield:

(+/-)-1-<3-Methoxy-4,5-(methylenedioxy)benzyl>propanol (119425-99-9) → 1-(7-methoxy-benzo[1,3]dioxol-5-yl)-propan-1-one (19937-86-1)

Guidance literature:

With jones reagent; In acetone; Yield given; 1.) 0-5 deg C, 10 min., 2.) room temperature, 30 min.;

DOI:10.1021/jo00327a026

Reference yield:

5-hydroxyvanillin (3934-87-0) → 1-(7-methoxy-benzo[1,3]dioxol-5-yl)-propan-1-one (19937-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KF / dimethylformamide / 1.5 h / Heating

2: 1.) Mg, Vitride (Eastman) / 1.) ether, 2.) 30 min.

3: Jones reagent / acetone / 1.) 0-5 deg C, 10 min., 2.) room temperature, 30 min.

With potassium fluoride; jones reagent; magnesium; sodium bis(2-methoxyethoxy)aluminium dihydride; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jo00327a026

upstream raw materials:

sodium methylate

diazomethane

1-(3,4-methylenedioxy-5-hydroxyphenyl)propan-1-one

(+/-)-1-<3-Methoxy-4,5-(methylenedioxy)benzyl>propanol

Refernces

• 1、 Bagirov, V. Yu.,Belyi, M. B.. "STUDY OF SOME REPRESENTATIVES OF THE FAMILY Umbelliferae". . p. 230 - 231. Retrieved 1982.
• 2、 -. "PROPENONE DERIVATIVES". . . Retrieved 2008/06/13.