2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide

Base Information

Chemical Name:2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
CAS No.:210755-45-6
Molecular Formula:C₁₆H₁₇FN₂O₅S
Molecular Weight:368.386
Hs Code.:
European Community (EC) Number:663-608-0
UNII:96U47H947L
DSSTox Substance ID:DTXSID40175302
Wikidata:Q27271931
Pharos Ligand ID:TLRJKFA6YTWF
ChEMBL ID:CHEMBL323612
Mol file:210755-45-6.mol

Synonyms:210755-45-6;CP 471474;CP-471474;2-[[[4-(4-FLUOROPHENOXY)PHENYL]SULFONYL]AMINO]-N-HYDROXY-2-METHYLPROPANAMIDE;CHEMBL323612;2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide;Propanamide, 2-(((4-(4-fluorophenoxy)phenyl)sulfonyl)amino)-N-hydroxy-2-methyl-;96U47H947L;Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-;UNII-96U47H947L;PF-1626077;SCHEMBL4652358;DTXSID40175302;QCOQJYRPDUMCNP-UHFFFAOYSA-N;HMS3262O11;Tox21_500715;BDBM50148231;2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide;AKOS024457796;CCG-222019;CS-W011801;HY-W011085;2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide;NCGC00261400-01;FT-0665212;E98884;CP-471474, >=98% (HPLC);J-013821;Q27271931;2-(((4-(4-fluorophenoxy)phenyl)sulfonyl)amino)-N-hydroxy-2-methyl-Propanamide;2-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-N-hydroxy-2-methyl-propionamide

Suppliers and Price of 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CP-471474
25mg
$ 270.00

Tocris
CP471474 ≥97%(HPLC)
10
$ 159.00

Tocris
CP471474 ≥97%(HPLC)
50
$ 603.00

Sigma-Aldrich
CP-471474 ≥98% (HPLC)
25mg
$ 423.00

Sigma-Aldrich
CP-471474 ≥98% (HPLC)
5mg
$ 109.00

Matrix Scientific
2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide 95%
1g
$ 2960.00

Cayman Chemical
CP 471,474
10mg
$ 136.00

Cayman Chemical
CP 471,474
5mg
$ 76.00

Cayman Chemical
CP 471,474
1mg
$ 28.00

Axon Medchem
CP471474 99%
2 x 10 mg
$ 154.00

Total 10 raw suppliers

Chemical Property of 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide

Chemical Property:

PKA:9.33±0.50(Predicted)
PSA：116.60000
Density:1.375±0.06 g/cm3(Predicted)
LogP:4.49230
Storage Temp.:Store at -20°C
Solubility.:DMSO: ≥20mg/mL
XLogP3:2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:368.08422098
Heavy Atom Count:25
Complexity:547

Purity/Quality:

97% ^*data from raw suppliers

CP-471474 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)NO)NS(=O)(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)F
Description CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.
Uses A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

Technology Process of 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide

There total 1 articles about 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: