N,N-DiBoc-2-amino-4-bromopyridine

Base Information

• Chemical Name: N,N-DiBoc-2-amino-4-bromopyridine
• CAS No.: 1216620-65-3
• Molecular Formula: C₁₅H₂₁BrN₂O₄
• Molecular Weight: 373.247
• Hs Code.: 2933399090
• Mol file: 1216620-65-3.mol

Synonyms:N,N-DiBoc-2-amino-4-bromopyridine;N,N-Di(tert-butoxycarbonyl)-4-bromopyridine-2-amine

Chemical Property of N,N-DiBoc-2-amino-4-bromopyridine

Chemical Property:

• Boiling Point: 414.4±55.0 °C(Predicted)
• PKA: 0.45±0.10(Predicted)
• PSA: 68.73000
• Density: 1.352±0.06 g/cm3(Predicted)
• LogP: 4.52070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-Diboc-2-amino-4-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DiBoc-2-amino-4-bromopyridine

There total 1 articles about N,N-DiBoc-2-amino-4-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-amino-4-bromopyridine (84249-14-9) + di-tert-butyl dicarbonate (24424-99-5) → C15H21BrN2O4 (1216620-65-3)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃;

Reference yield:

C15H21BrN2O4 (1216620-65-3) → 2-N-Boc Amino-4-(2-amino ethyl)pyridine (190189-67-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 13 h / 25 - 80 °C / Inert atmosphere

2: hydrogen; palladium on activated charcoal / methanol / 24 h / 25 °C / 2585.81 Torr

3: sodium hydroxide; methanol / 17 h / 25 °C

4: triethylamine; diphenylphosphoranyl azide / 1,4-dioxane / 2.17 h / 25 - 90 °C / Inert atmosphere

With methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; diphenylphosphoranyl azide; hydrogen; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-amino-4-bromopyridine

di-tert-butyl dicarbonate

Downstream raw materials:

2-N-Boc Amino-4-(2-amino ethyl)pyridine

Refernces

• 1、 -. "Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof". Paragraph 0577-0582. . Retrieved 2021/07/28.
• 2、 -. "AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF". Paragraph 0207; 0215; 0567. . Retrieved 2018/12/02.