(2R,4R)-2-methylpiperidin-4-ol

Base Information

• Chemical Name: (2R,4R)-2-methylpiperidin-4-ol
• CAS No.: 89451-59-2
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• DSSTox Substance ID: DTXSID901293774
• Mol file: 89451-59-2.mol

Synonyms:(2R,4R)-2-methylpiperidin-4-ol;89451-59-2;cis-2-methylpiperidin-4-ol;rac-(2R,4R)-2-methylpiperidin-4-ol, cis;1421310-00-0;(2R,4R)-2-Methyl-piperidin-4-ol;starbld0000404;cis-2-Methyl-piperidin-4-ol;SCHEMBL15476472;DTXSID901293774;rac-(2R,4R)-2-methylpiperidin-4-ol;4-Piperidinol, 2-methyl-, (2R-cis)-;WS-00535;EN300-331831;F70459

Chemical Property of (2R,4R)-2-methylpiperidin-4-ol

Chemical Property:

• Boiling Point: 191.7±15.0 °C(Predicted)
• PKA: 14.95±0.40(Predicted)
• PSA: 32.26000
• Density: 0.964±0.06 g/cm3(Predicted)
• LogP: 0.44800
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

97% ^*data from raw suppliers

(2R,4R)-2-Methylpiperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC(CCN1)O
• Isomeric SMILES: C[C@@H]1C[C@@H](CCN1)O

Technology Process of (2R,4R)-2-methylpiperidin-4-ol

There total 4 articles about (2R,4R)-2-methylpiperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-Cbz-6-amino-4-hydroxyhexan-2-one → (2R,4R)-2-methylpiperidin-4-ol (89451-59-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; water; at 20 ℃; under 1900.13 Torr; stereoselective reaction;

DOI:10.1002/adsc.201801530

Reference yield:

1,2-dimethyl-4-piperidone iodomethylate (27806-90-2) → (2R,4R)-2-methylpiperidin-4-ol (89451-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂O

2: 93 percent / NaBH₄

3: H₂ / Pd

With sodium tetrahydroborate; hydrogen; palladium; In water;

DOI:10.1007/BF00842851

Reference yield:

(-)-cis-1-(S-α-phenylethyl)-2-methyl-4-piperidol (89451-57-0) → (2R,4R)-2-methylpiperidin-4-ol (89451-59-2)

Guidance literature:

With hydrogen; palladium;

DOI:10.1007/BF00842851

upstream raw materials:

(-)-cis-1-(S-α-phenylethyl)-2-methyl-4-piperidol

1,2-dimethyl-4-piperidone iodomethylate

(R)-2-methyl-1-((S)-1-phenylethyl)piperidin-4-one

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