(3S,5S)-(5-Methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(3S,5S)-(5-Methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester
CAS No.:139161-75-4
Molecular Formula:C₁₀H₂₀N₂O₂
Molecular Weight:0
Hs Code.:

Synonyms:(3S,5S)-(5-Methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester;tert-Butyl ((3S,5S)-5-methylpyrrolidin-3-yl)carbamate

Suppliers and Price of (3S,5S)-(5-Methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 8 raw suppliers

Chemical Property of (3S,5S)-(5-Methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S,5S)-(5-Methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester

There total 11 articles about (3S,5S)-(5-Methyl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 139161-74-3
(2S,4S)-4-t-butoxycarbonylamino-2-methyl-1-N-benzylpyrrolidine

: 139161-75-4,1626343-40-5,181141-39-9
(2S,4S)-4-t-Butoxycarbonylamino-2-methylpyrrolidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 72h; under 3040 Torr; Ambient temperature;
DOI:10.1016/0040-4039(95)01813-W

Reference yield:

: 152673-17-1
(3S)-⁽³⁾-Benzyl-(cyanomethyl)aminobutanonitrile

: 139161-75-4,1626343-40-5,181141-39-9
(2S,4S)-4-t-Butoxycarbonylamino-2-methylpyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: KO-tBu / toluene / 1.25 h / 0 deg C up to RT

2: conc. HCl / 66 h / RT down to -80 deg C

3: H₂ / Pt / methanol / 23 °C

4: DEAD/PPh₃ / tetrahydrofuran / 0.33 h / Ambient temperature

5: N₂H₄ / ethanol / 3 h / Heating

6: methanol; H₂O / 16 h / Ambient temperature

7: 90 percent / H₂ / 10percent Pd/C / methanol / 72 h / 3040 Torr / Ambient temperature

With hydrogenchloride; potassium tert-butylate; hydrogen; triphenylphosphine; hydrazine; diethylazodicarboxylate; palladium on activated charcoal; platinum; In tetrahydrofuran; methanol; ethanol; water; toluene;
DOI:10.1016/0040-4039(95)01813-W

Reference yield:

: 173066-70-1
(S)-3-Amino-1-benzyl-5-methyl-4,5-dihydro-1H-pyrrole-2-carbonitrile

: 139161-75-4,1626343-40-5,181141-39-9
(2S,4S)-4-t-Butoxycarbonylamino-2-methylpyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: conc. HCl / 66 h / RT down to -80 deg C

2: H₂ / Pt / methanol / 23 °C

3: DEAD/PPh₃ / tetrahydrofuran / 0.33 h / Ambient temperature

4: N₂H₄ / ethanol / 3 h / Heating

5: methanol; H₂O / 16 h / Ambient temperature

6: 90 percent / H₂ / 10percent Pd/C / methanol / 72 h / 3040 Torr / Ambient temperature

With hydrogenchloride; hydrogen; triphenylphosphine; hydrazine; diethylazodicarboxylate; palladium on activated charcoal; platinum; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1016/0040-4039(95)01813-W