2,3,6,7-TETRAMETHYLQUINOXALINE

Base Information

• Chemical Name: 2,3,6,7-TETRAMETHYLQUINOXALINE
• CAS No.: 6957-19-3
• Molecular Formula: C₁₂H₁₄N₂
• Molecular Weight: 186.257
• Hs Code.: 2933990090
• Mol file: 6957-19-3.mol

Synonyms:2,3,6,7-Tetramethylquinoxaline;NSC 66172;2,3,6,7-tetramethylquinoxaline;quinoxaline, 2,3,6,7-tetramethyl-;

Chemical Property of 2,3,6,7-TETRAMETHYLQUINOXALINE

Chemical Property:

• Vapor Pressure: 0.00185mmHg at 25°C
• Refractive Index: 1.595
• Boiling Point: 301.7 °C at 760 mmHg
• Flash Point: 124.1 °C
• PSA: 25.78000
• Density: 1.063 g/cm³
• LogP: 2.86340

Purity/Quality:

98%min ^*data from raw suppliers

2,3,6,7-Tetramethylquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,3,6,7-TETRAMETHYLQUINOXALINE

There total 5 articles about 2,3,6,7-TETRAMETHYLQUINOXALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4,5-dimethyl-2-nitrobenzenamine (6972-71-0) + 2.3-butanediol (513-85-9) → 2,3,6,7-tetramethylquinoxaline (6957-19-3,95035-21-5)

Guidance literature:

With sodium hydroxide; In toluene; at 120 ℃; for 3h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.joc.0c02453

Reference yield: 94.0%

4,5-dimethyl-1,2-phenylenediamine (3171-45-7) + dimethylglyoxal (431-03-8) → 2,3,6,7-tetramethylquinoxaline (6957-19-3,95035-21-5)

Guidance literature:

With ammonium chloride; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol2029096

Reference yield: 87.0%

4,5-dimethyl-1,2-phenylenediamine (3171-45-7) + 2.3-butanediol (513-85-9) → 2,3,6,7-tetramethylquinoxaline (6957-19-3,95035-21-5)

Guidance literature:

With 1,10-Phenanthroline; cesiumhydroxide monohydrate; nickel dibromide; In toluene; at 150 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.9b03104

upstream raw materials:

4,5-dimethyl-1,2-phenylenediamine

dimethylglyoxal

7,8-dimethyl-2,3-bis(bromomethyl)quinoxaline

4,5-dimethyl-2-nitrobenzenamine

Refernces

• 1、 Wang, Yan-Bing,Shi, Linlin,Zhang, Xiaojie,Fu, Lian-Rong,Hu, Weinan,Zhang, Wenjing,Zhu, Xinju,Hao, Xin-Qi,Song, Mao-Ping. "NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy". . p. 947 - 958. Retrieved 2021/01/14.
• 2、 Sun, Kangkang,Li, Dandan,Lu, Guo-Ping,Cai, Chun. "Hydrogen Auto-transfer Synthesis of Quinoxalines from o-Nitroanilines and Biomass-based Diols Catalyzed by MOF-derived N,P Co-doped Cobalt Catalysts". . p. 373 - 381. Retrieved 2020/12/09.