Diethyl 2-isopropyl-3-oxosuccinate

Base Information

• Chemical Name: Diethyl 2-isopropyl-3-oxosuccinate
• CAS No.: 59916-75-5
• Molecular Formula: C11H18O5
• Molecular Weight: 230.261
• Mol file: 59916-75-5.mol

Synonyms:Diethyl 2-isopropyl-3-oxosuccinate

Chemical Property of Diethyl 2-isopropyl-3-oxosuccinate

Chemical Property:

• PSA: 69.67000
• LogP: 0.95390
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Diethyl2-isopropyl-3-oxosuccinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl 2-isopropyl-3-oxosuccinate

There total 2 articles about Diethyl 2-isopropyl-3-oxosuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

Ethyl isovalerate (108-64-5) + oxalic acid diethyl ester (95-92-1) → 2-isopropyl-3-oxo-succinic acid diethyl ester (59916-75-5)

Guidance literature:

Ethyl isovalerate; With sodium hydride; In tetrahydrofuran;

oxalic acid diethyl ester; In tetrahydrofuran;

DOI:10.1246/cl.1999.1313

Reference yield:

oxalic acid diethyl ester (95-92-1) → 2-isopropyl-3-oxo-succinic acid diethyl ester (59916-75-5)

Guidance literature:

With diethyl ether;

Reference yield: 99.0%

2-isopropyl-3-oxo-succinic acid diethyl ester (59916-75-5) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 2-[(4-fluorophenyl)-hydrazono]-3-isopropyl-succinic acid diethyl ester (1260620-86-7)

Guidance literature:

In water; acetonitrile; at 40 - 50 ℃; for 24h; Large scale reaction;

DOI:10.1021/op100268e

upstream raw materials:

Ethyl isovalerate

oxalic acid diethyl ester

Downstream raw materials:

4-methyl-2-oxopentanoic acid

2-Isopropyl-3-(methyl-phenyl-hydrazono)-succinic acid diethyl ester

1-(4-fluorophenyl)-4-isopropyl-5-trifluoromethanesulfonyloxy-1H-pyrazole-3-carboxylic acid ethyl ester

2-[(4-fluorophenyl)-hydrazono]-3-isopropyl-succinic acid diethyl ester

Refernces