NebraMine Disulfate

Base Information

• Chemical Name: NebraMine Disulfate
• CAS No.: 71122-29-7
• Molecular Formula: C₁₂H₂₆N₄O₅*2H₂O₄S
• Molecular Weight: 502.521
• Mol file: 71122-29-7.mol

Synonyms:NebraMine Disulfate;2-Deoxy-4-O-(2,6-diaMino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl)-D-streptaMine Disulfate;3'-DeoxyneaMin Disulfate;3'-DeoxyneaMine Disulfate;3'-DeoxyneoMycin A Disulfate;NebraMycin VIII Disulfate;TobraMine Disulfate

Chemical Property of NebraMine Disulfate

Chemical Property:

• PSA: 183.23000
• LogP: -1.28520

Purity/Quality:

98% ^*data from raw suppliers

NebramineSulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A degradation product on the antibiotic Tobramycin (T524000).

Technology Process of NebraMine Disulfate

There total 4 articles about NebraMine Disulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-epi-3,2',6',3''-tetra-N-formyl-1-N-hydroxytobramycin (84247-32-5,84278-34-2) → 1-epi-nebramine (71122-29-7,71155-49-2,84278-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 87.5 percent / H₂ / Raney Ni / ethanol; H₂O / 16 h / 3677.5 Torr / Ambient temperature

2: 510 mg / concd. hydrochloric acid / H₂O; methanol / 24 h / 36 °C

3: 50 mg / 4M hydrochloric acid / 4.5 h / 110 °C

With hydrogenchloride; hydrogen; nickel; In methanol; ethanol; water;

DOI:10.1016/0008-6215(82)84032-9

Reference yield:

3,2',6',3''-tetra-N-formyl-1-N-hydroxytobramycin (84247-32-5,84278-34-2) → 1-epi-nebramine (71122-29-7,71155-49-2,84278-33-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 33 mg / H₂ / Raney Ni / ethanol / 16 h / 3677.5 Torr / Ambient temperature

2: 85 percent / 30percent H₂O₂, sodium tungstate / H₂O / 4 h / 20 °C

3: 49.8 percent / LiCl, 1M HCl / 4 h / electrochemical reduction

4: 510 mg / concd. hydrochloric acid / H₂O; methanol / 24 h / 36 °C

5: 50 mg / 4M hydrochloric acid / 4.5 h / 110 °C

With hydrogenchloride; sodium tungstate; hydrogen; dihydrogen peroxide; lithium chloride; nickel; In methanol; ethanol; water;

DOI:10.1016/0008-6215(82)84032-9

Reference yield:

1-epi-tobramycin (84278-18-2) → 1-epi-nebramine (71122-29-7,71155-49-2,84278-33-1)

Guidance literature:

With hydrogenchloride; at 110 ℃; for 4.5h;

DOI:10.1016/0008-6215(82)84032-9

upstream raw materials:

1-epi-tobramycin

3,2',6',3''-tetra-N-formyl-1-N-hydroxytobramycin

1-epi-3,2',6',3''-tetra-N-formyl-1-N-hydroxytobramycin

3,2',6',3''-tetra-N-formyltobramycin

Refernces