1-Piperidineacetic acid, 3-(carboxyMethylene)-α-(2-chlorophenyl)-4-Mercapto-, 1-Methyl ester, (αS)-

Base Information

Chemical Name:1-Piperidineacetic acid, 3-(carboxyMethylene)-α-(2-chlorophenyl)-4-Mercapto-, 1-Methyl ester, (αS)-
CAS No.:1147350-77-3
Molecular Formula:C16H18ClNO4S
Molecular Weight:355.842
Hs Code.:
Mol file:1147350-77-3.mol

Synonyms:1-Piperidineacetic acid, 3-(carboxyMethylene)-α-(2-chlorophenyl)-4-Mercapto-, 1-Methyl ester, (αS)-;Clopidogrel active Metabolite;CLOPIDOGREL ACTIVE METABOLITE / (2Z)-2-[1-[(1S)-1-(2-CHLOROPHENYL)-2-METHOXY-2-OXOETHYL]-4-SULFANYLPIPERIDIN-3-YLIDENE]ACETIC ACID

Suppliers and Price of 1-Piperidineacetic acid, 3-(carboxyMethylene)-α-(2-chlorophenyl)-4-Mercapto-, 1-Methyl ester, (αS)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
(2Z)-2-[1-[(1S)-1-(2-CHLOROPHENYL)-2-METHOXY-2-OXOETHYL]-4-SULFANYLPIPERIDIN-3-YLIDENE]ACETIC ACID 95.00%
5G
$ 505.16

Total 8 raw suppliers

Chemical Property of 1-Piperidineacetic acid, 3-(carboxyMethylene)-α-(2-chlorophenyl)-4-Mercapto-, 1-Methyl ester, (αS)-

Chemical Property:

PSA：105.64000
LogP:2.50710

Purity/Quality:

99% ^*data from raw suppliers

(2Z)-2-[1-[(1S)-1-(2-CHLOROPHENYL)-2-METHOXY-2-OXOETHYL]-4-SULFANYLPIPERIDIN-3-YLIDENE]ACETIC ACID 95.00% ^*data from reagent suppliers

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Hazard Codes:

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Technology Process of 1-Piperidineacetic acid, 3-(carboxyMethylene)-α-(2-chlorophenyl)-4-Mercapto-, 1-Methyl ester, (αS)-

There total 10 articles about 1-Piperidineacetic acid, 3-(carboxyMethylene)-α-(2-chlorophenyl)-4-Mercapto-, 1-Methyl ester, (αS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113665-84-2,94188-84-8
(S)-(+)-clopidogrel

: 1147350-77-3,767612-34-0
cis-5-thiol metabolite

Guidance literature:: Enzymatic reaction;

Reference yield:

: 90055-48-4,94188-84-8
clopidogrel

: 1147350-77-3,767612-34-0
cis-5-thiol metabolite

Guidance literature:: Multi-step reaction with 2 steps

1.1: L-CSA*1H₂O / toluene / 49 h / 20 - 50 °C / Resolution of racemate

1.2: 6 h / Resolution of racemate; Reflux

2.1: Enzymatic reaction

With L-CSA*1H₂O; In toluene;

Reference yield:

: 2856-63-5
2-Chlorophenylacetonitrile

: 1147350-77-3,767612-34-0
cis-5-thiol metabolite

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / 6 h / 105 - 110 °C

2.1: sodium hydrogencarbonate / methanol / 3 h / Reflux

3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; butan-1-ol / 12 h / Reflux

4.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / methanol; water / 0.5 h / Reflux

4.2: 12 h / 40 °C

5.1: L-CSA*1H₂O / toluene / 49 h / 20 - 50 °C / Resolution of racemate

5.2: 6 h / Resolution of racemate; Reflux

6.1: Enzymatic reaction

With N-benzyl-N,N,N-triethylammonium chloride; bromine; sodium hydrogencarbonate; sodium hydroxide; In methanol; water; toluene; butan-1-ol;