MB-07133

Base Information

Chemical Name:MB-07133
CAS No.:1190389-15-1
Molecular Formula:C26H28N4O3
Molecular Weight:444.533
Hs Code.:
Mol file:1190389-15-1.mol

Synonyms:(6S)-N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide;(6S)-N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-α]pyrimidine-6-carboxamide;

Suppliers and Price of MB-07133

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 29 raw suppliers

Chemical Property of MB-07133

Chemical Property:

PKA:13.55±0.70(Predicted)
PSA：96.25000
Density:1.36±0.1 g/cm3(Predicted)
LogP:3.16780

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Vibegron is a potent and selective β3 Adrenergic receptor agonist for the treatment of overactive bladder.

Technology Process of MB-07133

There total 28 articles about MB-07133 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1295539-30-8
(R)-((2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl)(phenyl)methanol

: C₈H₇N₂O₃^(1-)*Na⁽¹⁺⁾

: 1190389-15-1
(6S)-N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide

Guidance literature:: With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; isopropyl alcohol; at 5 - 15 ℃; for 1h; pH=3.1 - 3.7; Inert atmosphere;
DOI:10.1002/anie.201802791

Reference yield: 60.0%

: 1190393-25-9
tert-butyl(2R,5S)-2-[(R)-hydroxy(phenyl)methyl]-5-[4-({[(6S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-α]pyrimidin-6-yl]carbonyl}amino)benzyl]pyrrolidine-1-carboxylate

: 1190389-15-1
(6S)-N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide

Guidance literature:: tert-butyl(2R,5S)-2-[(R)-hydroxy(phenyl)methyl]-5-[4-({[(6S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-α]pyrimidin-6-yl]carbonyl}amino)benzyl]pyrrolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydrogencarbonate; pH=8 - 9;

Reference yield:

: tert-butyl (4S,5R)-4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

: 1190389-15-1
(6S)-N-[4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 40 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / acetone / 24 h / 20 °C

3.1: triethylamine / dichloromethane / 48 h / 20 °C

4.1: hydrogenchloride; water / ethyl acetate / 5 h / 20 - 45 °C

4.2: 7 h / 20 °C

4.3: 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

7.2: pH 8 - 9

With hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;