2(1H)-Isoquinolinecarboxylic acid, 1-[(3,4-diMethoxyphenyl)Methyl]-3,4-dihydro-6,7-diMethoxy-3-oxo-, 1,1-diMethylethyl ester, (S)- (9CI)

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 1-[(3,4-diMethoxyphenyl)Methyl]-3,4-dihydro-6,7-diMethoxy-3-oxo-, 1,1-diMethylethyl ester, (S)- (9CI)
CAS No.:178208-17-8
Molecular Formula:C25H31NO7
Molecular Weight:457.51614
Hs Code.:

Synonyms:2(1H)-Isoquinolinecarboxylic acid, 1-[(3,4-diMethoxyphenyl)Methyl]-3,4-dihydro-6,7-diMethoxy-3-oxo-, 1,1-diMethylethyl ester, (S)- (9CI)

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 1-[(3,4-diMethoxyphenyl)Methyl]-3,4-dihydro-6,7-diMethoxy-3-oxo-, 1,1-diMethylethyl ester, (S)- (9CI)

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Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 1-[(3,4-diMethoxyphenyl)Methyl]-3,4-dihydro-6,7-diMethoxy-3-oxo-, 1,1-diMethylethyl ester, (S)- (9CI)

There total 4 articles about 2(1H)-Isoquinolinecarboxylic acid, 1-[(3,4-diMethoxyphenyl)Methyl]-3,4-dihydro-6,7-diMethoxy-3-oxo-, 1,1-diMethylethyl ester, (S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 178357-78-3
(S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,4-dihydro-2H-isoquinolin-3-one

: 178208-17-8
(S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 4h; Heating;
DOI:10.1021/jo960110h

Reference yield:

: 26954-85-8
o-homoveratroylhomoveratric acid

: 178208-17-8
(S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / toluene / 14 h / Heating

2: 90 percent / Red-Al / toluene / 6 h / -30 °C

3: 85 percent / ammonia, Na / tetrahydrofuran / 0.01 h / Heating

4: 50 percent / DMAP, Et₃N / CH₂Cl₂ / 4 h / Heating

With dmap; ammonia; sodium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo960110h

Reference yield:

: 178208-19-0
(S)-1-(3,4-Dimethoxy-benzyl)-2-((S)-2-hydroxy-1-phenyl-ethyl)-6,7-dimethoxy-1,4-dihydro-2H-isoquinolin-3-one

: 178208-17-8
(S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / ammonia, Na / tetrahydrofuran / 0.01 h / Heating

2: 50 percent / DMAP, Et₃N / CH₂Cl₂ / 4 h / Heating

With dmap; ammonia; sodium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo960110h