EPZ020411

Base Information

• Chemical Name: EPZ020411
• CAS No.: 1700663-41-7
• Molecular Formula: C25H38N4O3
• Molecular Weight: 442.59
• Mol file: 1700663-41-7.mol

Synonyms:EPZ020411;N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine;EPZ020411 HCl

Chemical Property of EPZ020411

Chemical Property:

• Boiling Point: 619.2±55.0 °C(Predicted)
• PKA: 14.53±0.50(Predicted)
• PSA: 71.64000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 3.86190
• Solubility.: Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

EPZ020411HCl >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of EPZ020411

There total 2 articles about EPZ020411 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

tert-butyl methyl(2-(methyl((1-(tetrahydro-2H-pyran-2-yl)-3-(4-(3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)amino)ethyl)carbamate → N1,N2-dimethyl-N1-((3-(4-(3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine bis(2,2,2-trifluoroacetate) (1700663-41-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/acsmedchemlett.5b00071

Reference yield:

tert-butyl 2-(((3-(4-(3-(benzyloxy)cyclobutoxy)phenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)methyl)(methyl)amino)ethyl(methyl)carbamate → N1,N2-dimethyl-N1-((3-(4-(3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine bis(2,2,2-trifluoroacetate) (1700663-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / tetrahydrofuran; water / 4 h / 20 °C / 1520.1 Torr

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.2: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acsmedchemlett.5b00071

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