2H-Pyran-2-carboxaldehyde, tetrahydro-6-methoxy-5-methyl-, (2S,5S,6S)- (9CI)

Base Information

Chemical Name:2H-Pyran-2-carboxaldehyde, tetrahydro-6-methoxy-5-methyl-, (2S,5S,6S)- (9CI)
CAS No.:478693-75-3
Molecular Formula:C₈H₁₄O₃
Molecular Weight:158.197
Hs Code.:
Mol file:478693-75-3.mol

Synonyms:2H-Pyran-2-carboxaldehyde, tetrahydro-6-methoxy-5-methyl-, (2S,5S,6S)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Pyran-2-carboxaldehyde, tetrahydro-6-methoxy-5-methyl-, (2S,5S,6S)- (9CI)

Chemical Property:

PSA：35.53000
LogP:0.97290

Purity/Quality:

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Technology Process of 2H-Pyran-2-carboxaldehyde, tetrahydro-6-methoxy-5-methyl-, (2S,5S,6S)- (9CI)

There total 5 articles about 2H-Pyran-2-carboxaldehyde, tetrahydro-6-methoxy-5-methyl-, (2S,5S,6S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 478693-67-3
methyl 2-C-methyl-2,3,4-trideoxy-α-D-threo-hexopyranoside

: 478693-75-3
(2S,5S,6S)-6-Methoxy-5-methyl-tetrahydro-pyran-2-carbaldehyde

Guidance literature:: With 4 A molecular sieve; sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; pentane; at 20 ℃; for 2.5h;
DOI:10.1055/s-2002-34380

Reference yield:

: 68907-47-1
methyl 4,6-O-benzylidene-2-deoxy-2-C-methyl-α-D-altro-pyranoside

: 478693-75-3
(2S,5S,6S)-6-Methoxy-5-methyl-tetrahydro-pyran-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / Et₃SiH; TFA / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 154.0 mg / pyridine; DMAP / 7 h / -10 - 20 °C

3: 95 percent / Zn; NaI / dimethylformamide / 24 h / Heating

4: 99 percent / H₂ / 5 percent Pd/C / methanol / 5 h / 760 Torr

5: Dess-Martin periodinane; NaHCO₃; molecular sieves 4 Angstroem / CH₂Cl₂; pentane / 2.5 h / 20 °C

With pyridine; triethylsilane; dmap; 4 A molecular sieve; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; trifluoroacetic acid; sodium iodide; zinc; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1055/s-2002-34380

Reference yield:

: 142041-83-6
methyl 2,3,4-trideoxy-2-C-methyl-6-O-benzyl α-D-threo-hex-3-enopyranoside

: 478693-75-3
(2S,5S,6S)-6-Methoxy-5-methyl-tetrahydro-pyran-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / 5 percent Pd/C / methanol / 5 h / 760 Torr

2: Dess-Martin periodinane; NaHCO₃; molecular sieves 4 Angstroem / CH₂Cl₂; pentane / 2.5 h / 20 °C

With 4 A molecular sieve; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; palladium on activated charcoal; In methanol; dichloromethane; pentane;
DOI:10.1055/s-2002-34380