Technology Process of 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-diMethoxybenzoic Acid
(Donepezil IMpurity)
There total 1 articles about 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-diMethoxybenzoic Acid
(Donepezil IMpurity) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
donepezil hydrochloride;
With
sodium methylate; sodium hydroxide;
In
toluene;
at 0 - 25 ℃;
for 0.5h;
With
oxalic acid diethyl ester;
In
toluene;
at 20 - 25 ℃;
With
dihydrogen peroxide; sodium hydroxide;
In
methanol;
at 20 - 25 ℃;
for 24h;
Reagent/catalyst;
Solvent;
Temperature;