TERT-BUTYL 1H,4H,5H,6H,7H-IMIDAZO[4,5-C]PYRIDINE-5-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 1H,4H,5H,6H,7H-IMIDAZO[4,5-C]PYRIDINE-5-CARBOXYLATE
• CAS No.: 1202800-68-7
• Molecular Formula: C11H17N3O2
• Molecular Weight: 223.275
• Mol file: 1202800-68-7.mol

Synonyms:TERT-BUTYL 1H,4H,5H,6H,7H-IMIDAZO[4,5-C]PYRIDINE-5-CARBOXYLATE;tert-butyl 6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate;TERT-BUTYL 6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-CARBOXYLATE

Chemical Property of TERT-BUTYL 1H,4H,5H,6H,7H-IMIDAZO[4,5-C]PYRIDINE-5-CARBOXYLATE

Chemical Property:

• Boiling Point: 415.8±45.0 °C(Predicted)
• PKA: 14.32±0.20(Predicted)
• PSA: 58.22000
• Density: 1.200±0.06 g/cm3(Predicted)
• LogP: 1.64080

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl6,7-Dihydro-1H-imidazo[4,5-c]pyridine-5(4H)-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 1H,4H,5H,6H,7H-IMIDAZO[4,5-C]PYRIDINE-5-CARBOXYLATE

There total 10 articles about TERT-BUTYL 1H,4H,5H,6H,7H-IMIDAZO[4,5-C]PYRIDINE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6,7-dihydro-4H-imidazo[4,5-c]pyridine-1,5-dicarboxylic acid di-tert-butyl ester (1421503-52-7) → 1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (1202800-68-7)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 1h;

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + 4,5,6,7-tetrahydro-1H-imidazo<4,5-c>pyridine (6882-74-2) → 1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (1202800-68-7)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

Reference yield: 69.0%

4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine hydrochloride (879668-17-4) + di-tert-butyl dicarbonate (24424-99-5) → 1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (1202800-68-7)

Guidance literature:

4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine hydrochloride; di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; for 20h; Inert atmosphere;

With ammonia; In methanol; for 15h;

upstream raw materials:

di-tert-butyl dicarbonate

4,5,6,7-tetrahydro-1H-imidazo<4,5-c>pyridine

4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine hydrochloride

4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine hydrochloride

Downstream raw materials:

1-phenyl-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester

2-iodo-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester

2-[6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-3-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester

tert-butyl 1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate

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