6-(TRIFLUOROMETHYL)-2(3H)-BENZOTHIAZOLONEHYDRAZONE

Base Information

• Chemical Name: 6-(TRIFLUOROMETHYL)-2(3H)-BENZOTHIAZOLONEHYDRAZONE
• CAS No.: 898748-31-7
• Molecular Formula: C₈H₆F₃N₃S
• Molecular Weight: 233.217
• Mol file: 898748-31-7.mol

Synonyms:6-(TRIFLUOROMETHYL)-2(3H)-BENZOTHIAZOLONEHYDRAZONE

Chemical Property of 6-(TRIFLUOROMETHYL)-2(3H)-BENZOTHIAZOLONEHYDRAZONE

Chemical Property:

• PSA: 79.18000
• LogP: 3.37400

Purity/Quality:

98% ^*data from raw suppliers

2-HYRAZINYL-6-TRIFLUOROMETHYLBENZOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(TRIFLUOROMETHYL)-2(3H)-BENZOTHIAZOLONEHYDRAZONE

There total 1 articles about 6-(TRIFLUOROMETHYL)-2(3H)-BENZOTHIAZOLONEHYDRAZONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

2-amino-6-trifluoromethyl-1,3-benzothiazole (777-12-8) → 2-hydrazinyl-6-(trifluoromethyl)benzothiazole (898748-31-7)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In 1,2-dimethoxyethane; water; at 160 ℃; for 3h;

DOI:10.1021/acs.jmedchem.9b01429

Reference yield: 28.0%

5-(5-acetylfuran-2-yl)-2-chlorobenzoic acid (1135871-42-9) + 2-hydrazinyl-6-(trifluoromethyl)benzothiazole (898748-31-7) → 2-chloro-5-(5-(1-(2-(6-(trifluoromethyl)benzothiazol-2-yl)-hydrazono)ethyl)furan-2-yl)benzoic acid (1135869-08-7)

Guidance literature:

With acetic acid; In ethanol; at 60 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jm400556w

upstream raw materials:

2-amino-6-trifluoromethyl-1,3-benzothiazole

Downstream raw materials:

2-chloro-5-(5-(1-(2-(6-(trifluoromethyl)benzothiazol-2-yl)-hydrazono)ethyl)furan-2-yl)benzoic acid

Refernces

• 1、 Sleebs, Brad E.,Kersten, Wilhemus J. A.,Kulasegaram, Sanji,Nikolakopoulos, George,Hatzis, Effie,Moss, Rebecca M.,Parisot, John P.,Yang, Hong,Czabotar, Peter E.,Fairlie, W. Douglas,Lee, Erinna F.,Adams, Jerry M.,Chen, Lin,Van Delft, Mark F.,Lowes, Kym N.,Wei, Andrew,Huang, David C.S.,Colman, Peter M.,Street, Ian P.,Baell, Jonathan B.,Watson, Keith,Lessene, Guillaume. "Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL". . p. 5514 - 5540. Retrieved 2013/07/26.