7,8-Dihydromorphine-6-glucuronide

Base Information

Chemical Name:7,8-Dihydromorphine-6-glucuronide
CAS No.:70001-26-2
Molecular Formula:
Molecular Weight:463.48
Hs Code.:
DSSTox Substance ID:DTXSID801018775
Nikkaji Number:J1.274.871J
Mol file:70001-26-2.mol

Synonyms:70001-26-2;DTXSID801018775;7,8-Dihydromorphine-6-glucuronide

Suppliers and Price of 7,8-Dihydromorphine-6-glucuronide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Dihydromorphine-3-D-glucuronide solution 1.0 mg/mL in methanol: water (1:1), certified reference material
108-1ml
$ 144.00

Total 0 raw suppliers

Chemical Property of 7,8-Dihydromorphine-6-glucuronide

Chemical Property:

Boiling Point:727.0±60.0 °C(Predicted)
PKA:2.80±0.70(Predicted)
Density:1.61±0.1 g/cm3(Predicted)
Storage Temp.:-20°C
XLogP3:-1.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:463.18423150
Heavy Atom Count:33
Complexity:798

Purity/Quality:: Dihydromorphine-3-D-glucuronide solution 1.0 mg/mL in methanol: water (1:1), certified reference material ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(CC4)OC6C(C(C(C(O6)C(=O)O)O)O)O
Isomeric SMILES:CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](CC4)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O
Uses Dihydromorphine 6-O-β-D-Glucuronide is a metabolite of Hydromorphone (H714650).

Technology Process of 7,8-Dihydromorphine-6-glucuronide

There total 9 articles about 7,8-Dihydromorphine-6-glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 330823-63-7
C₃₂H₃₉NO₁₄

: 70001-26-2
Dihydromorphine 6-β-D-glucuronide

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃;
DOI:10.1016/S0040-4020(00)01080-2

Reference yield:

: 509-60-4,13004-73-4,26626-12-0
dihydromorphine

: 70001-26-2
Dihydromorphine 6-β-D-glucuronide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NaHCO₃ / methanol; CH₂Cl₂ / 1 h / 0 - 20 °C

2: 75 percent / 3 Angstroem molecular sieves; ZnBr₂ / CHCl₃ / Heating

3: 85 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; 3 A molecular sieve; sodium hydrogencarbonate; zinc dibromide; In methanol; dichloromethane; chloroform;
DOI:10.1016/S0040-4020(00)01080-2

Reference yield:

: 57820-69-6
(3R,4S,5S,6S)-2-bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 70001-26-2
Dihydromorphine 6-β-D-glucuronide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 3 Angstroem molecular sieves; ZnBr₂ / CHCl₃ / Heating

2: 85 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; 3 A molecular sieve; zinc dibromide; In methanol; chloroform;
DOI:10.1016/S0040-4020(00)01080-2