Difluoro-Biindolylpyrrolidine acetate

Base Information

Chemical Name:Difluoro-Biindolylpyrrolidine acetate
CAS No.:1260251-26-0
Molecular Formula:C30H32F2N4O4
Molecular Weight:550.5962864
Hs Code.:
Mol file:1260251-26-0.mol

Synonyms:Difluoro-Biindolylpyrrolidine acetate;3,4-Difluoro-1H,1'H-2,2'-biindole 2-(pyrrolidin-1-yl)acetate;(3S,3'S,5R,5'R)-5,5'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis(methylene)]bis-3-pyrrolidinol 3,3'-diacetate

Suppliers and Price of Difluoro-Biindolylpyrrolidine acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3,4-Difluoro-1H,1'H-2,2'-biindole2-(pyrrolidin-1-yl)acetate 95+%
250mg
$ 392.00

Crysdot
3,4-Difluoro-1H,1'H-2,2'-biindole2-(pyrrolidin-1-yl)acetate 95+%
1g
$ 982.00

Chemenu
3,4-Difluoro-1H,1''H-2,2''-biindole2-(pyrrolidin-1-yl)acetate 95%
1g
$ 926.00

Alichem
3,4-Difluoro-1H,1'H-2,2'-biindole2-(pyrrolidin-1-yl)acetate
1g
$ 970.20

Alichem
3,4-Difluoro-1H,1'H-2,2'-biindole2-(pyrrolidin-1-yl)acetate
250mg
$ 403.92

Total 9 raw suppliers

Chemical Property of Difluoro-Biindolylpyrrolidine acetate

Chemical Property:

PSA：108.24000
LogP:4.92420

Purity/Quality:

97% ^*data from raw suppliers

3,4-Difluoro-1H,1'H-2,2'-biindole2-(pyrrolidin-1-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Difluoro-Biindolylpyrrolidine acetate

There total 41 articles about Difluoro-Biindolylpyrrolidine acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1260251-25-9
{4S-acetoxy-2R-[3'-(4S-acetoxy-1-benzyloxycarbonylpyrrolidin-2R-ylmethyl)-6,6'-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-1-yl}carboxylic acid benzyl ester

: 1260251-26-0
acetic acid 5-[3'-(4-acetoxypyrrolidin-2-ylmethyl)-6,6’-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-3-yl ester

Guidance literature:: With hydrogen bromide; acetic acid; In dichloromethane; at 20 ℃; for 48h; Reagent/catalyst; Solvent; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.5b00390

Reference yield:

: 1260251-25-9
{4S-acetoxy-2R-[3'-(4S-acetoxy-1-benzyloxycarbonylpyrrolidin-2R-ylmethyl)-6,6'-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-1-yl}carboxylic acid benzyl ester

: 1260251-26-0
acetic acid 5-[3'-(4-acetoxypyrrolidin-2-ylmethyl)-6,6’-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-3-yl ester

: C₂₈H₃₀F₂N₄O₃

Guidance literature:: With 5%-palladium/activated carbon; hydrogen bromide; In methanol; ethyl acetate; at 20 ℃; for 6h; under 2585.81 Torr; Reagent/catalyst; Time; Large scale;
DOI:10.1021/acs.oprd.5b00390

Reference yield:

: 1174655-34-5
(2S,4R)-4-(tert-butyldimethylsilyloxy)-2-(6-fluoro-1H-indole-3-carbonyl)pyrrolidine-1-carboxylic acid benzyl ester

: 1260251-26-0
acetic acid 5-[3'-(4-acetoxypyrrolidin-2-ylmethyl)-6,6’-difluoro-1H,1'H-[2,2']biindolyl-3-ylmethyl]pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 57 h / 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 17 h / 2 - 20 °C

3.1: methanol; sodium hydroxide / tetrahydrofuran; water / 2 h

4.1: lithium borohydride / tetrahydrofuran / 2.61 h

4.2: 16 h

5.1: dmap / dichloromethane / 16 h / 20 °C

6.1: trifluoroacetic acid / ethyl acetate / 4.75 h / 2 - 4 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / ethyl acetate / 3 h

8.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 3 h / 2585.81 Torr

With methanol; dmap; lithium borohydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;