5-chloro-2-Thiopheneacetic acid

Base Information

• Chemical Name: 5-chloro-2-Thiopheneacetic acid
• CAS No.: 13669-19-7
• Molecular Formula: C6H5ClO2S
• Molecular Weight: 176.624
• Hs Code.: 2934999090
• Mol file: 13669-19-7.mol

Synonyms:5-chloro-2-Thiopheneacetic acid

Chemical Property of 5-chloro-2-Thiopheneacetic acid

Chemical Property:

• PSA: 65.54000
• LogP: 2.02860

Purity/Quality:

NLT 98% ^*data from raw suppliers

(5-Chloro-2-Thienyl)AceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2-Thiopheneacetic acid

There total 10 articles about 5-chloro-2-Thiopheneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Thiophene-2-acetic acid (1918-77-0) → 2-(5-chlorothiophen-2-yl)acetic acid (13669-19-7)

Guidance literature:

With N-chloro-succinimide; acetic acid;

DOI:10.1016/j.bmcl.2010.03.059

Reference yield:

[2-(5-chlorocthiophen-2-yl)-1-dimethylaminovinyl]phosphonic acid diethyl ester (234108-05-5) → 2-(5-chlorothiophen-2-yl)acetic acid (13669-19-7)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating / reflux;

Reference yield:

5-Chloro-2-thiophenecarboxaldehyde (7283-96-7) + methyl methylsulfinylmethyl sulfide (33577-16-1) → 2-(5-chlorothiophen-2-yl)acetic acid (13669-19-7)

Guidance literature:

methyl methylsulfinylmethyl sulfide; With sodium hydroxide; at 70 ℃; for 0.5h;

5-Chloro-2-thiophenecarboxaldehyde; at 70 ℃;

upstream raw materials:

methyl (5-chlorothien-2-yl)acetate

5-Chlorothiophene-2-carboxylic acid

5-chlorothiophene-2-carbonyl chloride

2-Chloro-5-(chloromethyl)thiophene

Downstream raw materials:

4-chloro-2-[2-(5-chlorothiophen-2-yl)-acetylamino]-5-iodo-benzoic acid methyl ester

(5-chlorothien-2-yl)(1-hydroxycyclohexyl)acetic acid

(R)-4-benzyl-3-(2-(5-chlorothiophen-2-yl)acetyl)oxazolidin-2-one

3-[2-(5-chloro-thiophen-2-yl)-acetylamino]-4-(1-ethyl-propylamino)-benzoic acid methyl ester

Refernces

• 1、 Sabatucci, Joseph P.,Mahaney, Paige E.,Leiter, Jennifer,Johnston, Grace,Burroughs, Kevin,Cosmi, Scott,Zhang, Yingru,Ho, Douglas,Deecher, Darlene C.,Trybulski, Eugene. "Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors". scheme or table. p. 2809 - 2812. Retrieved 2010/08/21.
• 2、 Young, Jonathan R.,Huang, Song X.,Chen, Irene,Walsh, Thomas F.,DeVita, Robert J.,Wyvratt Jr., Matthew J.,Goulet, Mark T.,Ren, Ning,Lo, Jane,Yang, Yi Tien,Yudkovitz, Joel B.,Cheng, Kang,Smith, Roy G.. "Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents". . p. 1723 - 1727. Retrieved 2007/10/03.