(5β)-Estr-1-ene-3,17-dione

Base Information

• Chemical Name: (5β)-Estr-1-ene-3,17-dione
• CAS No.: 101469-27-6
• Molecular Formula: C18H24O2
• Molecular Weight: 272.387
• Mol file: 101469-27-6.mol

Synonyms:(5β)-Estr-1-ene-3,17-dione;(5beta)-Estr-1-ene-3,17-dione

Chemical Property of (5β)-Estr-1-ene-3,17-dione

Chemical Property:

• PSA: 34.14000
• LogP: 3.55320

Purity/Quality:

(5β)-Estr-1-ene-3,17-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (5β)-Estr-1-ene-3,17-dione, can be used for the synthesis of some kind of Cardenolides and bufadienolides, being able to bind to and inhibit the activity of the plasma membrane Na+/K+ ATPase.

Technology Process of (5β)-Estr-1-ene-3,17-dione

There total 4 articles about (5β)-Estr-1-ene-3,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2α-bromo-5β-estrane-3,17-dione (102922-53-2) → 5β-estr-1-ene-3,17-dione (101469-27-6)

Guidance literature:

With ISOPROPYLAMIDE; calcium carbonate; for 0.25h; Heating;

DOI:10.1021/jo00365a040

Reference yield: 5.0%

2α-bromo-5β-estrane-3,17-dione (102922-53-2) → estra-4-ene-3,17-dione (734-32-7) + 5β-estr-1-ene-3,17-dione (101469-27-6)

Guidance literature:

With pyridine; for 12h; Heating;

DOI:10.1021/jo00365a040

Reference yield:

5β-estrane-3,17-dione (5696-51-5) → estra-4-ene-3,17-dione (734-32-7) + 5β-estr-1-ene-3,17-dione (101469-27-6)

Guidance literature:

With Phenylselenyl chloride; dihydrogen peroxide; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1039/c39850001479

upstream raw materials:

5β-estrane-3,17-dione

2α-bromo-5β-estrane-3,17-dione

Refernces

• 1、 Abul-Hajj, Y. J.. "A Reinvestigation of the Reaction of Bromine with 5β-Estrane-3,17-dione". . p. 3059 - 3061. Retrieved 1986.