1-(5-Fluoro-pyrimidin-2-yl)-piperidin-4-ol

Base Information

• Chemical Name: 1-(5-Fluoro-pyrimidin-2-yl)-piperidin-4-ol
• CAS No.: 1001397-31-4
• Molecular Formula: C₉H₁₂FN₃O
• Molecular Weight: 197.212
• Mol file: 1001397-31-4.mol

Synonyms:1-(5-Fluoro-pyrimidin-2-yl)-piperidin-4-ol

Chemical Property of 1-(5-Fluoro-pyrimidin-2-yl)-piperidin-4-ol

Chemical Property:

• PSA: 49.25000
• LogP: 0.64180

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Fluoropyrimidin-2-yl)piperidin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Fluoro-pyrimidin-2-yl)-piperidin-4-ol

There total 2 articles about 1-(5-Fluoro-pyrimidin-2-yl)-piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 2-chloro-5-fluoropyrimidine (62802-42-0) → 1-(5-fluoro-2-pyrimidinyl)-4-piperidinol (1001397-31-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 10h; Inert atmosphere; Reflux;

DOI:10.1021/jm301404a

Reference yield: 83.0%

→ 1-(5-fluoro-2-pyrimidinyl)-4-piperidinol (1001397-31-4)

Guidance literature:

Reference yield: 39.0%

1-(5-fluoro-2-pyrimidinyl)-4-piperidinol (1001397-31-4) + 4-chloro-7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (1001397-19-8) → 7-[2-fluoro-4-(methylsulfonyl)phenyl]-4-{[1-(5-fluoro-2-pyrimidinyl)-4-piperidinyl]oxy}-6,7-dihydro-5H-pyrrolo[2,3-d]-pyrimidine (1001397-32-5)

Guidance literature:

1-(5-fluoro-2-pyrimidinyl)-4-piperidinol; With sodium hydride; In tetrahydrofuran; for 0.5h; Reflux;

4-chloro-7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine; In tetrahydrofuran; at 20 ℃; for 1.5h; Reflux;

DOI:10.1021/jm301404a

upstream raw materials:

4-HYDROXYPIPERIDINE

2-chloro-5-fluoropyrimidine

Downstream raw materials:

7-[2-fluoro-4-(methylsulfonyl)phenyl]-4-{[1-(5-fluoro-2-pyrimidinyl)-4-piperidinyl]oxy}-6,7-dihydro-5H-pyrrolo[2,3-d]-pyrimidine

Refernces

• 1、 -. "GPR119 AGONISTS FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS". Page/Page column 73. . Retrieved 2010/11/29.