2,6-Dibromoterephthalic acid dimethyl ester

Base Information

• Chemical Name: 2,6-Dibromoterephthalic acid dimethyl ester
• CAS No.: 22191-59-9
• Molecular Formula: C10H8Br2O4
• Molecular Weight: 351.979
• Mol file: 22191-59-9.mol

Synonyms:2,6-Dibromoterephthalic acid dimethyl ester

Chemical Property of 2,6-Dibromoterephthalic acid dimethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 2.78480

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-Dibromoterephthalic acid dimethyl ester

There total 2 articles about 2,6-Dibromoterephthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-amino-3,5-dibromo-terephthalic acid dimethyl ester (328553-15-7) → 2,6-dibromo-terephthalic acid dimethyl ester (22191-59-9)

Guidance literature:

With sulfuric acid; sodium nitrite; In methanol; at 70 ℃; for 2h;

DOI:10.1055/s-2001-18066

Reference yield:

dimethyl aminoterephthalate (5372-81-6) → 2,6-dibromo-terephthalic acid dimethyl ester (22191-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Br₂ / CH₂Cl₂ / 12 h / 70 °C

2: 83 percent / H₂SO₄; NaNO₂ / methanol / 2 h / 70 °C

With sulfuric acid; bromine; sodium nitrite; In methanol; dichloromethane;

DOI:10.1055/s-2001-18066

Reference yield: 74.4%

2,6-dibromo-terephthalic acid dimethyl ester (22191-59-9) + 1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrene (349666-24-6) → 2-bromo-6-pyren-1-yl-terephthalic acid dimethyl ester (386267-54-5)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 72h; Heating;

DOI:10.1055/s-2001-18066

upstream raw materials:

2-amino-3,5-dibromo-terephthalic acid dimethyl ester

dimethyl aminoterephthalate

Downstream raw materials:

2-bromo-6-pyren-1-yl-terephthalic acid dimethyl ester

3-bromo-4'-pyren-1-yl-biphenyl-2,5-dicarboxylic acid dimethyl ester

Refernces