trans-1-Propenylboronic acid MIDA ester

Base Information

• Chemical Name: trans-1-Propenylboronic acid MIDA ester
• CAS No.: 1104637-46-8
• Molecular Formula: C₈H₁₂BNO₄
• Molecular Weight: 196.999
• Mol file: 1104637-46-8.mol

Synonyms:trans-1-Propenylboronic acid MIDA ester;

Chemical Property of trans-1-Propenylboronic acid MIDA ester

Chemical Property:

• Melting Point: 117-122°C
• PSA: 55.84000
• LogP: -0.44040

Purity/Quality:

trans-1-Propenylboronic acid MIDA ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for:Tandem intramolecular Michael addition/alkene migrationMIDA boronates as stable boronic acid surrogates for classically challenging cross-couplingsSuzuki Cross-Coupling with MIDA Boronates

Technology Process of trans-1-Propenylboronic acid MIDA ester

There total 1 articles about trans-1-Propenylboronic acid MIDA ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-propenylboronic acid (7547-96-8,7547-97-9,88982-39-2,6336-44-3) + N-methyliminodiacetic acid (4408-64-4) → C8H12BNO4 (1104637-46-8,1105069-15-5)

Guidance literature:

In dimethyl sulfoxide; at 80 ℃;

DOI:10.1021/acs.orglett.8b02234

Reference yield: 77.0%

C8H12BNO4 (1104637-46-8,1105069-15-5) + C19H18ClNO6 → C22H23NO6

Guidance literature:

C₈H₁₂BNO₄; C₁₉H₁₈ClNO₆; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere; Sealed tube;

With potassium phosphate; In tetrahydrofuran; water; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2019.03.037

Reference yield: 74.0%

C8H12BNO4 (1104637-46-8,1105069-15-5) + C31H26ClNO6 → C34H31NO6

Guidance literature:

C₈H₁₂BNO₄; C₃₁H₂₆ClNO₆; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere; Sealed tube;

With potassium phosphate; In tetrahydrofuran; water; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2019.03.037

upstream raw materials:

1-propenylboronic acid

N-methyliminodiacetic acid

Downstream raw materials:

1-propenylboronic acid