4H-Cyclopenta-1,3-dioxol-4-one, 3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,6aR)-

Base Information

• Chemical Name: 4H-Cyclopenta-1,3-dioxol-4-one, 3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,6aR)-
• CAS No.: 88559-56-2
• Molecular Formula: C28H26O4
• Molecular Weight: 426.512
• Mol file: 88559-56-2.mol

Synonyms:4H-Cyclopenta-1,3-dioxol-4-one, 3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,6aR)-;4H-Cyclopenta-1,3-dioxol-4-one, 3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,6aR)-7

Chemical Property of 4H-Cyclopenta-1,3-dioxol-4-one, 3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,6aR)-

Chemical Property:

• Melting Point: 161.2-163.2 °C
• Boiling Point: 547.6±50.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.175±0.06 g/cm3(Predicted)
• LogP: 5.02430

Purity/Quality:

97% ^*data from raw suppliers

(3AR,6aR)-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Cyclopenta-1,3-dioxol-4-one, 3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,6aR)-

There total 33 articles about 4H-Cyclopenta-1,3-dioxol-4-one, 3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,6aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(4R,5S)-4,5-O,O-isopropylidene-3-(trityloxymethyl)-2-cyclopenten-1-ol → (3aR,6aR)-2,2-dimethyl-6-[(trityloxy)methyl]-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one (88559-56-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2018.03.020

Reference yield: 92.0%

(3aS,4R,6aS)-2,2-dimethyl-4-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol (865838-13-7,681854-00-2) → (3aR,6aR)-2,2-dimethyl-6-[(trityloxy)methyl]-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one (88559-56-2)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo0356762

Reference yield: 30.0%

{2-[(4R,5S)-2,2-Dimethyl-5-(2-trityloxy-acetyl)-[1,3]dioxolan-4-yl]-2-oxo-ethyl}-phosphonic acid dimethyl ester (88559-55-1) → (3aR,6aR)-2,2-dimethyl-6-[(trityloxy)methyl]-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one (88559-56-2)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In toluene; at 65 ℃; for 2h;

DOI:10.1016/S0040-4039(00)88259-3

upstream raw materials:

{2-[(4R,5S)-2,2-Dimethyl-5-(2-trityloxy-acetyl)-[1,3]dioxolan-4-yl]-2-oxo-ethyl}-phosphonic acid dimethyl ester

{2-[(4R,5S)-2,2-Dimethyl-5-(2-trityloxy-acetyl)-[1,3]dioxolan-4-yl]-2-oxo-ethyl}-phosphonic acid diethyl ester

(3aS,4R,6aS)-2,2-dimethyl-4-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol

C₃₀H₃₂O₄

Downstream raw materials:

(3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

((3aS,4S,6aR)-4-(6-amino-9H-purin-9-yl)-5-fluoro-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-6-yl)methanol

(3aS,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

(3aS,4R,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

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