(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

Base Information

Chemical Name:(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
CAS No.:51833-69-3
Molecular Formula:C₄₉H₇₁N₁₃O₁₀
Molecular Weight:1002.18
Hs Code.:
Mol file:51833-69-3.mol

(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

Synonyms:1-Sar-5-Ile-angiotensin II;angiotensin II, Sar(1)-Ile(5)-;angiotensin II, Sar(1)-Ile(5)-, (5-L-allo-Ile)-isomer;angiotensin II, Sar(1)-Ile(5)-, (7-D-Pro)-isomer;angiotensin II, sarcosyl(1)-isoleucine(5)-;S1-AII

Suppliers and Price of (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：355.05000
Density:1.38g/cm³
LogP:3.17750
XLogP3:-0.7
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:28
Exact Mass:1001.54468551
Heavy Atom Count:72
Complexity:1840

Purity/Quality:: >98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC
Isomeric SMILES:CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC

Technology Process of (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

There total 3 articles about (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 35899-43-5
Boc-His(Tos)-OH

: 51833-69-3
(Sar1)angiotensin II

Guidance literature:: Multistep reaction;
DOI:10.1021/jm00114a012

Reference yield:

: 68858-20-8
Fmoc-Val-OH

: 71989-23-6,251316-98-0
Fmoc-Ile-OH

: 119831-72-0,157774-30-6
Fmoc-Arg(Pbf)-OH

: 77128-70-2
N-(9-fluorenylmethoxycarbonyl)sarcosine

: 51833-69-3
(Sar1)angiotensin II

Guidance literature:: Multistep reaction;

Reference yield:

: 51833-69-3,82043-64-9,85848-63-1,101833-55-0,111821-39-7,111821-44-4
C₄₉H₇₁N₁₃O₁₀

Guidance literature:: Z-Sar-Arg(NO2)-Val-Tyr(OCH2Ph)-Ile-His(CH2Ph)-Pro-Phe (Merrifield Festphasen-Synthese), 1) TFA/HBr(Gas); 2) H2/Pd (Me./Eg./W.);
DOI:10.1139/o74-018